Abdominal CT Metrics in 17,646 Patients Reveal Associations between Myopenia, Myosteatosis, and Medical Phenotypes: A Phenome-Wide Association Study

Juan Manuel Zambrano Chaves1, Leon Lenchik2, Isabel Gallegos1, Louis Blankemeier1, Tie Liang1, Daniel Rubin1, Marc Willis1, Akshay S Chaudhari1, Robert D Boutin1
1Stanford University    2Wake Forest University
Paper Code

Abstract

We identify associations between CT-derived biomarkers of muscle and hundreds of medical phenotypes.

Background: Deep learning facilitates large-scale automated imaging evaluation of body composition. However, associations of body composition biomarkers with medical phenotypes have been underexplored. Phenome-wide association study (PheWAS) techniques search for medical phenotypes associated with biomarkers. A PheWAS integrating large-scale analysis of imaging biomarkers and electronic health record (EHR) data could discover previously unreported associations and validate expected associations. Here we use PheWAS methodology to determine the association of abdominal CT-based skeletal muscle metrics with medical phenotypes in a large North American cohort.

Methods: An automated deep learning pipeline was used to measure skeletal muscle index (SMI; biomarker of myopenia) and skeletal muscle density (SMD; biomarker of myosteatosis) from abdominal CT scans of adults between 2012-2018. A PheWAS was performed with logistic regression using patient sex and age as covariates to assess for associations between CT-derived muscle metrics and 611 common EHR-derived medical phenotypes. PheWAS P values were considered significant at a Bonferroni corrected threshold (α=0.05/1222).

Findings: 17,646 adults (mean age, 56 years +/- 19 [SD]; 57.5% women) were included. CT-derived SMI was significantly associated with 268 medical phenotypes; SMD with 340 medical phenotypes. Previously unreported associations with the highest magnitude of significance included higher SMI with decreased cardiac dysrhythmias (OR [95%CI], 0.59 [0.55-0.64]; P<0.0001), decreased epilepsy (OR, 0.59 [0.50-0.70]; P<0.0001), and increased elevated prostate-specific antigen (OR, 1.84 [1.47-2.31]; P<0.0001), and higher SMD with decreased decubitus ulcers (OR, 0.36 [0.31-0.42]; P<0.0001), sleep disorders (OR, 0.39 [0.32-0.47]; P<0.0001), and osteomyelitis (OR, 0.43 [0.36-0.52]; P<0.0001).

Interpretation: PheWAS methodology reveals previously unreported associations between CT-derived biomarkers of myopenia and myosteatosis and EHR medical phenotypes. The high-throughput PheWAS technique applied on a population scale can generate research hypotheses related to myopenia and myosteatosis and can be adapted to research possible associations of other imaging biomarkers with hundreds of EHR medical phenotypes.

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SMI Results

Manhattan (above) and Volcano (below) plot of PheWAS associations between SMI and ICD-derived medical phenotypes. Statistically significant associations are marked in red. The horizontal red bar corresponds to the Bonferroni significance threshold (0.05/1222). SMI = skeletal muscle index, SMD = skeletal muscle density, ICD = International Classification of Diseases.

SMD Results

Manhattan (above) and Volcano (below) plot of PheWAS associations between SMD and ICD-derived medical phenotypes. Statistically significant associations are marked in red. The horizontal red bar corresponds to the Bonferroni significance threshold (0.05/1222). SMI = skeletal muscle index, SMD = skeletal muscle density, ICD = International Classification of Diseases.

Overall Results

Odds ratios for associations between SMI and SMD and ICD-derived phecodes. Only statistically significant associations for both SMI and SMD are displayed. Error bars correspond to 95% confidence intervals. SMI = skeletal muscle index, SMD = skeletal muscle density, ICD = International Classification of Diseases.



Associations between SMI and SMD with medical phenotypes. OR = odds ratio, CI = confidence interval. Note: P value is bonferroni normalized P value (i.e. P value * 1222)
Phenotype Description Phenotype Group Metric P Value OR (95% CI) Cases (n) Controls (n)
260 Protein-calorie malnutrition endocrine/metabolic SMI < 0.0001 0.30 (0.28 - 0.32) 1220 15673
278.1 Obesity endocrine/metabolic SMD < 0.0001 0.33 (0.31 - 0.35) 1350 16048
278 Overweight, obesity and other hyperalimentation endocrine/metabolic SMD < 0.0001 0.37 (0.34 - 0.39) 1591 16048
278.1 Obesity endocrine/metabolic SMI < 0.0001 2.25 (2.11 - 2.38) 1350 16054
278.11 Morbid obesity endocrine/metabolic SMD < 0.0001 0.28 (0.26 - 0.31) 655 16048
278 Overweight, obesity and other hyperalimentation endocrine/metabolic SMI < 0.0001 2.07 (1.96 - 2.19) 1592 16054
427 Cardiac dysrhythmias circulatory system SMD < 0.0001 0.54 (0.51 - 0.57) 3636 12600
426.7 Abnormal electrocardiogram [ECG] [EKG] circulatory system SMD < 0.0001 0.50 (0.47 - 0.52) 2656 12600
994 Sepsis and SIRS injuries & poisonings SMD < 0.0001 0.46 (0.43 - 0.49) 1676 15963
038 Septicemia infectious diseases SMD < 0.0001 0.46 (0.43 - 0.49) 1686 15348
994.2 Sepsis injuries & poisonings SMD < 0.0001 0.45 (0.42 - 0.48) 1588 15963
250 Diabetes mellitus endocrine/metabolic SMD < 0.0001 0.51 (0.48 - 0.54) 2395 14747
426 Cardiac conduction disorders circulatory system SMD < 0.0001 0.55 (0.52 - 0.57) 3578 12600
250.2 Type 2 diabetes endocrine/metabolic SMD < 0.0001 0.51 (0.48 - 0.54) 2193 14747
585 Renal failure genitourinary SMD < 0.0001 0.50 (0.47 - 0.53) 1829 14818
278.11 Morbid obesity endocrine/metabolic SMI < 0.0001 2.42 (2.24 - 2.62) 655 16054
276 Disorders of fluid, electrolyte, and acid-base balance endocrine/metabolic SMD < 0.0001 0.56 (0.53 - 0.59) 2544 14995
507 Pleurisy; pleural effusion respiratory SMD < 0.0001 0.50 (0.47 - 0.54) 1602 15342
401 Hypertension circulatory system SMD < 0.0001 0.61 (0.59 - 0.64) 4422 13217
514 Abnormal findings examination of lungs respiratory SMD < 0.0001 0.57 (0.54 - 0.60) 2656 14743
260.2 severe protein-calorie malnutrition endocrine/metabolic SMI < 0.0001 0.31 (0.27 - 0.34) 352 15673
427.7 Tachycardia NOS circulatory system SMD < 0.0001 0.47 (0.44 - 0.51) 1237 12600
276 Disorders of fluid, electrolyte, and acid-base balance endocrine/metabolic SMI < 0.0001 0.61 (0.58 - 0.64) 2545 15001
585.1 Acute renal failure genitourinary SMD < 0.0001 0.47 (0.44 - 0.51) 1097 14818
285 Other anemias hematopoietic SMD < 0.0001 0.58 (0.55 - 0.61) 2204 14700
509 Respiratory failure, insufficiency, arrest respiratory SMD < 0.0001 0.42 (0.38 - 0.46) 712 15342
276.1 Electrolyte imbalance endocrine/metabolic SMD < 0.0001 0.55 (0.52 - 0.58) 1749 14995
038 Septicemia infectious diseases SMI < 0.0001 0.57 (0.54 - 0.61) 1686 15355
401.1 Essential hypertension circulatory system SMD < 0.0001 0.64 (0.61 - 0.67) 4012 13217
285 Other anemias hematopoietic SMI < 0.0001 0.61 (0.58 - 0.65) 2205 14706
994 Sepsis and SIRS injuries & poisonings SMI < 0.0001 0.58 (0.55 - 0.62) 1676 15970
041 Bacterial infection NOS infectious diseases SMD < 0.0001 0.50 (0.46 - 0.53) 1100 15348
427.2 Atrial fibrillation and flutter circulatory system SMD < 0.0001 0.47 (0.43 - 0.51) 1234 12600
994.2 Sepsis injuries & poisonings SMI < 0.0001 0.58 (0.55 - 0.62) 1588 15970
427 Cardiac dysrhythmias circulatory system SMI < 0.0001 0.67 (0.64 - 0.70) 3636 12606
509.1 Respiratory failure respiratory SMD < 0.0001 0.41 (0.37 - 0.45) 589 15342
276.1 Electrolyte imbalance endocrine/metabolic SMI < 0.0001 0.59 (0.56 - 0.63) 1750 15001
507 Pleurisy; pleural effusion respiratory SMI < 0.0001 0.58 (0.55 - 0.62) 1602 15349
427.21 Atrial fibrillation circulatory system SMD < 0.0001 0.47 (0.43 - 0.51) 1180 12600
572 Ascites (non malignant) digestive SMD < 0.0001 0.55 (0.51 - 0.59) 1477 13909
514 Abnormal findings examination of lungs respiratory SMI < 0.0001 0.66 (0.63 - 0.69) 2656 14750
994.21 Septic shock injuries & poisonings SMD < 0.0001 0.35 (0.31 - 0.39) 380 15963
508 Pulmonary collapse; interstitial and compensatory emphysema respiratory SMD < 0.0001 0.46 (0.42 - 0.50) 683 15342
503 Pulmonary congestion and hypostasis respiratory SMD < 0.0001 0.41 (0.37 - 0.46) 519 15342
427.7 Tachycardia NOS circulatory system SMI < 0.0001 0.57 (0.53 - 0.61) 1237 12606
198 Secondary malignant neoplasm neoplasms SMI < 0.0001 0.65 (0.61 - 0.68) 2160 14143
707.1 Decubitus ulcer dermatologic SMI < 0.0001 0.34 (0.30 - 0.39) 238 17300
585.3 Chronic renal failure [CKD] genitourinary SMD < 0.0001 0.48 (0.44 - 0.53) 828 14818
260.3 Adult failure to thrive endocrine/metabolic SMI < 0.0001 0.34 (0.30 - 0.39) 244 15673
458.9 Hypotension NOS circulatory system SMD < 0.0001 0.44 (0.40 - 0.48) 570 16641
195 Cancer, suspected or other neoplasms SMI < 0.0001 0.61 (0.57 - 0.64) 1452 14143
428 Congestive heart failure; nonhypertensive circulatory system SMD < 0.0001 0.50 (0.46 - 0.55) 820 16703
560 Intestinal obstruction without mention of hernia digestive SMI < 0.0001 0.63 (0.60 - 0.67) 1698 11805
458 Hypotension circulatory system SMD < 0.0001 0.50 (0.46 - 0.54) 741 16641
681 Superficial cellulitis and abscess dermatologic SMD < 0.0001 0.52 (0.48 - 0.57) 823 16721
571 Chronic liver disease and cirrhosis digestive SMD < 0.0001 0.62 (0.58 - 0.66) 1717 13909
452 Other venous embolism and thrombosis circulatory system SMD < 0.0001 0.57 (0.53 - 0.62) 1178 15238
292.4 Altered mental status mental disorders SMI < 0.0001 0.54 (0.49 - 0.58) 805 16104
512 Other symptoms of respiratory system respiratory SMD < 0.0001 0.67 (0.64 - 0.71) 2608 15031
292.4 Altered mental status mental disorders SMD < 0.0001 0.51 (0.47 - 0.56) 805 16099
292 Neurological disorders mental disorders SMD < 0.0001 0.56 (0.52 - 0.61) 1117 16099
707 Chronic ulcer of skin dermatologic SMD < 0.0001 0.39 (0.35 - 0.45) 346 17293
276.6 Fluid overload endocrine/metabolic SMD < 0.0001 0.36 (0.31 - 0.41) 275 14995
512.7 Shortness of breath respiratory SMD < 0.0001 0.62 (0.58 - 0.66) 1556 15031
707 Chronic ulcer of skin dermatologic SMI < 0.0001 0.44 (0.40 - 0.50) 346 17300
572 Ascites (non malignant) digestive SMI < 0.0001 0.64 (0.60 - 0.68) 1477 13915
426.7 Abnormal electrocardiogram [ECG] [EKG] circulatory system SMI < 0.0001 0.69 (0.66 - 0.73) 2657 12606
782.3 Edema symptoms SMD < 0.0001 0.55 (0.51 - 0.60) 877 16728
292 Neurological disorders mental disorders SMI < 0.0001 0.60 (0.56 - 0.65) 1118 16104
276.4 Acid-base balance disorder endocrine/metabolic SMD < 0.0001 0.41 (0.37 - 0.47) 354 14995
327.3 Sleep apnea neurological SMD < 0.0001 0.57 (0.53 - 0.62) 977 15923
585.32 End stage renal disease genitourinary SMD < 0.0001 0.39 (0.34 - 0.44) 293 14818
296 Mood disorders mental disorders SMD < 0.0001 0.67 (0.63 - 0.71) 2152 14160
571.5 Other chronic nonalcoholic liver disease digestive SMD < 0.0001 0.62 (0.58 - 0.66) 1386 13909
296.2 Depression mental disorders SMD < 0.0001 0.66 (0.62 - 0.70) 1947 14160
041 Bacterial infection NOS infectious diseases SMI < 0.0001 0.62 (0.58 - 0.66) 1100 15355
783 Fever of unknown origin symptoms SMD < 0.0001 0.67 (0.63 - 0.71) 1943 15696
427.3 Other specified cardiac dysrhythmias circulatory system SMD < 0.0001 0.55 (0.50 - 0.60) 814 12600
458 Hypotension circulatory system SMI < 0.0001 0.57 (0.53 - 0.62) 741 16647
560.4 Other intestinal obstruction digestive SMI < 0.0001 0.64 (0.60 - 0.68) 1300 11805
327.32 Obstructive sleep apnea neurological SMD < 0.0001 0.56 (0.52 - 0.61) 834 15923
285.2 Anemia of chronic disease hematopoietic SMI < 0.0001 0.54 (0.49 - 0.59) 581 14706
707.1 Decubitus ulcer dermatologic SMD < 0.0001 0.36 (0.31 - 0.42) 238 17293
567 Peritonitis and retroperitoneal infections digestive SMD < 0.0001 0.59 (0.55 - 0.64) 1039 14829
275 Disorders of mineral metabolism endocrine/metabolic SMD < 0.0001 0.54 (0.49 - 0.59) 671 16968
415 Pulmonary heart disease circulatory system SMD < 0.0001 0.55 (0.50 - 0.60) 770 16487
416 Cardiomegaly circulatory system SMD < 0.0001 0.48 (0.43 - 0.54) 485 16487
038.3 Bacteremia infectious diseases SMD < 0.0001 0.50 (0.45 - 0.56) 557 15348
509.1 Respiratory failure respiratory SMI < 0.0001 0.55 (0.51 - 0.60) 589 15349
509 Respiratory failure, insufficiency, arrest respiratory SMI < 0.0001 0.58 (0.53 - 0.63) 712 15349
798 Malaise and fatigue symptoms SMI < 0.0001 0.69 (0.66 - 0.73) 1832 15814
427.3 Other specified cardiac dysrhythmias circulatory system SMI < 0.0001 0.59 (0.55 - 0.64) 814 12606
198.4 Secondary malignant neoplasm of liver neoplasms SMI < 0.0001 0.60 (0.56 - 0.65) 789 14143
250.3 Insulin pump user endocrine/metabolic SMD < 0.0001 0.50 (0.44 - 0.55) 487 14747
585.31 Renal dialysis genitourinary SMD < 0.0001 0.39 (0.34 - 0.45) 238 14818
994.21 Septic shock injuries & poisonings SMI < 0.0001 0.51 (0.46 - 0.56) 380 15970
452.2 Deep vein thrombosis [DVT] circulatory system SMD < 0.0001 0.53 (0.48 - 0.58) 575 15238
458.9 Hypotension NOS circulatory system SMI < 0.0001 0.56 (0.51 - 0.61) 570 16647
275 Disorders of mineral metabolism endocrine/metabolic SMI < 0.0001 0.59 (0.54 - 0.64) 672 16974
426 Cardiac conduction disorders circulatory system SMI < 0.0001 0.75 (0.72 - 0.79) 3579 12606
285.2 Anemia of chronic disease hematopoietic SMD < 0.0001 0.53 (0.48 - 0.58) 581 14700
428.1 Congestive heart failure (CHF) NOS circulatory system SMD < 0.0001 0.48 (0.43 - 0.54) 435 16703
276.41 Acidosis endocrine/metabolic SMD < 0.0001 0.42 (0.36 - 0.48) 282 14995
569 Other disorders of intestine digestive SMI < 0.0001 0.68 (0.64 - 0.72) 1367 14836
426.3 Bundle branch block circulatory system SMD < 0.0001 0.49 (0.44 - 0.55) 539 12600
287 Purpura and other hemorrhagic conditions hematopoietic SMD < 0.0001 0.55 (0.50 - 0.60) 617 16143
480 Pneumonia respiratory SMD < 0.0001 0.58 (0.53 - 0.63) 795 16737
287.3 Thrombocytopenia hematopoietic SMD < 0.0001 0.54 (0.49 - 0.60) 592 16143
401.2 Hypertensive heart and/or renal disease circulatory system SMD < 0.0001 0.49 (0.43 - 0.55) 465 13217
276.5 Hypovolemia endocrine/metabolic SMI < 0.0001 0.60 (0.56 - 0.65) 742 15001
288 Diseases of white blood cells hematopoietic SMD < 0.0001 0.59 (0.54 - 0.64) 822 15441
285.1 Acute posthemorrhagic anemia hematopoietic SMD < 0.0001 0.53 (0.48 - 0.58) 547 14700
279 Disorders involving the immune mechanism endocrine/metabolic SMD < 0.0001 0.52 (0.47 - 0.58) 474 17077
569 Other disorders of intestine digestive SMD < 0.0001 0.66 (0.61 - 0.70) 1367 14829
317 Alcohol-related disorders mental disorders SMD < 0.0001 0.53 (0.48 - 0.59) 513 15498
585.1 Acute renal failure genitourinary SMI < 0.0001 0.66 (0.61 - 0.70) 1097 14825
555 Inflammatory bowel disease and other gastroenteritis and colitis digestive SMI < 0.0001 0.60 (0.55 - 0.65) 650 11805
317.1 Alcoholism mental disorders SMD < 0.0001 0.52 (0.47 - 0.58) 462 15498
276.14 Hypopotassemia endocrine/metabolic SMI < 0.0001 0.59 (0.54 - 0.64) 643 15001
198.6 Secondary malignancy of bone neoplasms SMI < 0.0001 0.55 (0.50 - 0.60) 446 14143
276.12 Hyposmolality and/or hyponatremia endocrine/metabolic SMD < 0.0001 0.58 (0.53 - 0.63) 765 14995
427.6 Premature beats circulatory system SMD < 0.0001 0.49 (0.43 - 0.55) 463 12600
276.12 Hyposmolality and/or hyponatremia endocrine/metabolic SMI < 0.0001 0.60 (0.55 - 0.66) 765 15001
428.3 Heart failure with reduced EF [Systolic or combined heart failure] circulatory system SMD < 0.0001 0.49 (0.44 - 0.56) 414 16703
480 Pneumonia respiratory SMI < 0.0001 0.63 (0.58 - 0.68) 795 16744
284 Aplastic anemia hematopoietic SMD < 0.0001 0.50 (0.44 - 0.56) 401 14700
452.2 Deep vein thrombosis [DVT] circulatory system SMI < 0.0001 0.58 (0.53 - 0.64) 575 15244
452 Other venous embolism and thrombosis circulatory system SMI < 0.0001 0.68 (0.63 - 0.72) 1179 15244
038.3 Bacteremia infectious diseases SMI < 0.0001 0.58 (0.53 - 0.64) 557 15355
290.2 Delirium due to conditions classified elsewhere mental disorders SMD < 0.0001 0.41 (0.36 - 0.48) 240 16099
539 Bariatric surgery digestive SMD < 0.0001 0.53 (0.47 - 0.59) 478 17161
291 Other specified nonpsychotic and/or transient mental disorders mental disorders SMD < 0.0001 0.49 (0.44 - 0.56) 380 16099
276.4 Acid-base balance disorder endocrine/metabolic SMI < 0.0001 0.52 (0.47 - 0.59) 354 15001
512.9 Other dyspnea respiratory SMD < 0.0001 0.59 (0.53 - 0.64) 704 15031
318 Tobacco use disorder mental disorders SMD < 0.0001 0.69 (0.64 - 0.73) 1554 15498
260.6 Anorexia endocrine/metabolic SMI < 0.0001 0.49 (0.43 - 0.55) 302 15673
284.1 Pancytopenia hematopoietic SMD < 0.0001 0.50 (0.44 - 0.56) 391 14700
198.3 Secondary malignant neoplasm of digestive systems neoplasms SMI < 0.0001 0.61 (0.56 - 0.66) 653 14143
260 Protein-calorie malnutrition endocrine/metabolic SMD < 0.0001 0.66 (0.61 - 0.71) 1220 15668
317.11 Alcoholic liver damage mental disorders SMD < 0.0001 0.43 (0.37 - 0.50) 225 15498
291.8 Alteration of consciousness mental disorders SMD < 0.0001 0.48 (0.42 - 0.54) 340 16099
288.1 Decreased white blood cell count hematopoietic SMI < 0.0001 0.61 (0.56 - 0.67) 613 15447
288.2 Elevated white blood cell count hematopoietic SMD < 0.0001 0.60 (0.55 - 0.66) 752 15441
288.1 Decreased white blood cell count hematopoietic SMD < 0.0001 0.58 (0.53 - 0.64) 613 15441
571.8 Liver abscess and sequelae of chronic liver disease digestive SMD < 0.0001 0.58 (0.53 - 0.64) 661 13909
285.21 Anemia in chronic kidney disease hematopoietic SMD < 0.0001 0.39 (0.33 - 0.46) 178 14700
198.2 Secondary malignancy of respiratory organs neoplasms SMI < 0.0001 0.56 (0.51 - 0.62) 408 14143
288.11 Neutropenia hematopoietic SMD < 0.0001 0.56 (0.51 - 0.62) 515 15441
411 Ischemic Heart Disease circulatory system SMD < 0.0001 0.66 (0.61 - 0.71) 1325 16264
591 Urinary tract infection genitourinary SMD < 0.0001 0.67 (0.62 - 0.72) 1186 15562
198.5 Secondary malignancy of brain/spine neoplasms SMI < 0.0001 0.47 (0.41 - 0.54) 180 14143
501 Pneumonitis due to inhalation of food or vomitus respiratory SMI < 0.0001 0.44 (0.38 - 0.51) 192 15349
567 Peritonitis and retroperitoneal infections digestive SMI < 0.0001 0.69 (0.64 - 0.74) 1039 14836
272 Disorders of lipoid metabolism endocrine/metabolic SMI < 0.0001 1.29 (1.23 - 1.35) 2884 14762
291 Other specified nonpsychotic and/or transient mental disorders mental disorders SMI < 0.0001 0.55 (0.49 - 0.61) 381 16104
425 Cardiomyopathy circulatory system SMD < 0.0001 0.50 (0.44 - 0.57) 332 17102
272.1 Hyperlipidemia endocrine/metabolic SMI < 0.0001 1.29 (1.23 - 1.35) 2873 14762
559 Ileostomy status digestive SMI < 0.0001 0.52 (0.47 - 0.59) 267 11805
560.1 Paralytic ileus digestive SMD < 0.0001 0.52 (0.46 - 0.59) 371 11799
276.14 Hypopotassemia endocrine/metabolic SMD < 0.0001 0.59 (0.54 - 0.65) 642 14995
338 Pain neurological SMD < 0.0001 0.74 (0.70 - 0.78) 2136 15503
291.8 Alteration of consciousness mental disorders SMI < 0.0001 0.54 (0.48 - 0.61) 340 16104
304 Adjustment reaction mental disorders SMI < 0.0001 0.57 (0.51 - 0.63) 367 14166
327.32 Obstructive sleep apnea neurological SMI < 0.0001 1.48 (1.38 - 1.60) 834 15928
296.22 Major depressive disorder mental disorders SMD < 0.0001 0.63 (0.58 - 0.69) 805 14160
426.31 Right bundle branch block circulatory system SMD < 0.0001 0.45 (0.38 - 0.52) 265 12600
286.2 Encounter for long-term (current) use of anticoagulants hematopoietic SMD < 0.0001 0.60 (0.55 - 0.66) 635 16143
290 Delirium dementia and amnestic and other cognitive disorders mental disorders SMI < 0.0001 0.58 (0.52 - 0.64) 590 16104
426.8 Other cardiac conduction disorders circulatory system SMD < 0.0001 0.46 (0.39 - 0.53) 236 12600
585 Renal failure genitourinary SMI < 0.0001 0.75 (0.71 - 0.79) 1829 14825
276.41 Acidosis endocrine/metabolic SMI < 0.0001 0.53 (0.47 - 0.60) 282 15001
783 Fever of unknown origin symptoms SMI < 0.0001 0.76 (0.73 - 0.80) 1943 15703
327.3 Sleep apnea neurological SMI < 0.0001 1.44 (1.34 - 1.54) 977 15928
300 Anxiety disorders mental disorders SMD < 0.0001 0.71 (0.66 - 0.76) 1502 14160
681.7 Cellulitis and abscess of trunk dermatologic SMD < 0.0001 0.50 (0.44 - 0.58) 298 16721
288.11 Neutropenia hematopoietic SMI < 0.0001 0.62 (0.57 - 0.68) 515 15447
427.22 Atrial flutter circulatory system SMD < 0.0001 0.44 (0.37 - 0.51) 235 12600
041.2 Streptococcus infection infectious diseases SMD < 0.0001 0.42 (0.36 - 0.50) 189 15348
279 Disorders involving the immune mechanism endocrine/metabolic SMI < 0.0001 0.62 (0.56 - 0.68) 474 17084
197 Chemotherapy neoplasms SMI < 0.0001 0.74 (0.70 - 0.78) 1450 14143
285.1 Acute posthemorrhagic anemia hematopoietic SMI < 0.0001 0.62 (0.57 - 0.68) 547 14706
425.1 Primary/intrinsic cardiomyopathies circulatory system SMD < 0.0001 0.50 (0.43 - 0.57) 278 17102
785 Abdominal pain symptoms SMD < 0.0001 1.22 (1.17 - 1.27) 11046 6593
345 Epilepsy, recurrent seizures, convulsions neurological SMD < 0.0001 0.55 (0.49 - 0.62) 379 16348
255.2 Adrenal hypofunction endocrine/metabolic SMD < 0.0001 0.37 (0.31 - 0.45) 118 16932
255.21 Glucocorticoid deficiency endocrine/metabolic SMD < 0.0001 0.37 (0.31 - 0.45) 118 16932
411.4 Coronary atherosclerosis circulatory system SMD < 0.0001 0.66 (0.61 - 0.72) 1024 16264
195.1 Malignant neoplasm, other neoplasms SMI < 0.0001 0.67 (0.61 - 0.72) 707 14143
560.1 Paralytic ileus digestive SMI < 0.0001 0.59 (0.53 - 0.65) 371 11805
426.9 Cardiac pacemaker/device in situ circulatory system SMD < 0.0001 0.50 (0.43 - 0.57) 313 12600
081 Infection/inflammation of internal prosthetic device; implant; and graft infectious diseases SMD < 0.0001 0.45 (0.39 - 0.53) 181 17208
288 Diseases of white blood cells hematopoietic SMI < 0.0001 0.69 (0.64 - 0.75) 822 15447
550 Abdominal hernia digestive SMD < 0.0001 0.71 (0.66 - 0.76) 1261 16378
508 Pulmonary collapse; interstitial and compensatory emphysema respiratory SMI < 0.0001 0.66 (0.61 - 0.72) 683 15349
290 Delirium dementia and amnestic and other cognitive disorders mental disorders SMD < 0.0001 0.59 (0.53 - 0.66) 590 16099
041.1 Staphylococcus infections infectious diseases SMD < 0.0001 0.47 (0.41 - 0.55) 227 15348
571.51 Cirrhosis of liver without mention of alcohol digestive SMD < 0.0001 0.60 (0.54 - 0.67) 534 13909
284 Aplastic anemia hematopoietic SMI < 0.0001 0.60 (0.55 - 0.67) 401 14706
401.1 Essential hypertension circulatory system SMI < 0.0001 1.22 (1.17 - 1.28) 4013 13223
555.2 Ulcerative colitis digestive SMI < 0.0001 0.58 (0.52 - 0.65) 321 11805
401.22 Hypertensive chronic kidney disease circulatory system SMD < 0.0001 0.51 (0.44 - 0.58) 290 13217
276.5 Hypovolemia endocrine/metabolic SMD < 0.0001 0.65 (0.59 - 0.71) 742 14995
275.5 Disorders of calcium/phosphorus metabolism endocrine/metabolic SMD < 0.0001 0.48 (0.41 - 0.56) 213 16968
568 Other disorders of peritoneum digestive SMD < 0.0001 0.61 (0.55 - 0.68) 548 14829
503 Pulmonary congestion and hypostasis respiratory SMI < 0.0001 0.63 (0.57 - 0.69) 519 15349
327.6 Circadian rhythm sleep disorder neurological SMD < 0.0001 0.39 (0.32 - 0.47) 118 15923
290.2 Delirium due to conditions classified elsewhere mental disorders SMI < 0.0001 0.52 (0.46 - 0.60) 240 16104
204 Leukemia neoplasms SMD < 0.0001 0.59 (0.53 - 0.66) 440 16677
798 Malaise and fatigue symptoms SMD < 0.0001 0.75 (0.71 - 0.80) 1832 15807
539 Bariatric surgery digestive SMI < 0.0001 1.53 (1.40 - 1.68) 478 17168
710 Osteomyelitis, periostitis, and other infections involving bone musculoskeletal SMD < 0.0001 0.43 (0.36 - 0.52) 155 17063
338.2 Chronic pain neurological SMD < 0.0001 0.70 (0.65 - 0.76) 1088 15503
480.1 Bacterial pneumonia respiratory SMI < 0.0001 0.47 (0.40 - 0.55) 126 16744
710.1 Osteomyelitis musculoskeletal SMD < 0.0001 0.43 (0.36 - 0.52) 154 17063
860 Bone marrow or stem cell transplant neoplasms SMD < 0.0001 0.50 (0.43 - 0.58) 216 17423
990 Effects radiation NOS injuries & poisonings SMI < 0.0001 0.65 (0.59 - 0.71) 547 15576
284.1 Pancytopenia hematopoietic SMI < 0.0001 0.61 (0.55 - 0.68) 391 14706
550.5 Ventral hernia digestive SMD < 0.0001 0.59 (0.53 - 0.66) 431 16378
276.13 Hyperpotassemia endocrine/metabolic SMD < 0.0001 0.48 (0.41 - 0.56) 202 14995
575 Other biliary tract disease digestive SMI < 0.0001 0.73 (0.69 - 0.78) 1119 15847
348 Other conditions of brain neurological SMD < 0.0001 0.55 (0.48 - 0.63) 328 16348
198 Secondary malignant neoplasm neoplasms SMD < 0.0001 0.77 (0.73 - 0.82) 2160 14136
300.1 Anxiety disorder mental disorders SMD < 0.0001 0.72 (0.67 - 0.78) 1281 14160
415.2 Chronic pulmonary heart disease circulatory system SMD < 0.0001 0.49 (0.42 - 0.57) 227 16487
575.2 Obstruction of bile duct digestive SMI < 0.0001 0.62 (0.56 - 0.69) 412 15847
509.8 Dependence on respirator [Ventilator] or supplemental oxygen respiratory SMD < 0.0001 0.40 (0.33 - 0.49) 119 15342
415.11 Pulmonary embolism and infarction, acute circulatory system SMD < 0.0001 0.58 (0.52 - 0.65) 392 16487
195 Cancer, suspected or other neoplasms SMD < 0.0001 0.74 (0.69 - 0.79) 1452 14136
415.1 Acute pulmonary heart disease circulatory system SMD < 0.0001 0.58 (0.52 - 0.66) 394 16487
288.2 Elevated white blood cell count hematopoietic SMI < 0.0001 0.70 (0.65 - 0.76) 752 15447
555.1 Regional enteritis digestive SMI < 0.0001 0.62 (0.56 - 0.69) 351 11805
536.7 Complications of gastrostomy, colostomy and enterostomy digestive SMI < 0.0001 0.48 (0.41 - 0.57) 132 16078
573.5 Jaundice (not of newborn) digestive SMI < 0.0001 0.60 (0.53 - 0.67) 331 13915
348.8 Encephalopathy, not elsewhere classified neurological SMD < 0.0001 0.47 (0.40 - 0.56) 194 16348
276.11 Hyperosmolality and/or hypernatremia endocrine/metabolic SMD < 0.0001 0.38 (0.31 - 0.48) 110 14995
041.2 Streptococcus infection infectious diseases SMI < 0.0001 0.53 (0.46 - 0.61) 189 15355
079 Viral infection infectious diseases SMD < 0.0001 0.55 (0.48 - 0.63) 283 16466
348 Other conditions of brain neurological SMI < 0.0001 0.60 (0.53 - 0.67) 328 16355
681.5 Cellulitis and abscess of leg, except foot dermatologic SMD < 0.0001 0.43 (0.35 - 0.52) 131 16721
280 Iron deficiency anemias hematopoietic SMI < 0.0001 0.72 (0.66 - 0.77) 822 14706
427.61 Supraventricular premature beats circulatory system SMD < 0.0001 0.46 (0.38 - 0.55) 191 12600
008.52 Intestinal infection due to C. difficile infectious diseases SMI < 0.0001 0.60 (0.54 - 0.68) 314 17040
427.6 Premature beats circulatory system SMI < 0.0001 0.61 (0.54 - 0.68) 463 12606
275.3 Disorders of magnesium metabolism endocrine/metabolic SMD < 0.0001 0.53 (0.46 - 0.62) 252 16968
561 Symptoms involving digestive system digestive SMI < 0.0001 0.80 (0.76 - 0.84) 1959 11805
429.1 Heart transplant/surgery circulatory system SMD < 0.0001 0.41 (0.33 - 0.50) 102 16703
008 Intestinal infection infectious diseases SMI < 0.0001 0.69 (0.63 - 0.75) 606 17040
348.8 Encephalopathy, not elsewhere classified neurological SMI < 0.0001 0.53 (0.46 - 0.61) 194 16355
117 Mycoses infectious diseases SMD < 0.0001 0.50 (0.43 - 0.59) 189 16933
250.2 Type 2 diabetes endocrine/metabolic SMI < 0.0001 1.24 (1.18 - 1.31) 2193 14753
401 Hypertension circulatory system SMI < 0.0001 1.19 (1.14 - 1.24) 4423 13223
427.1 Paroxysmal tachycardia, unspecified circulatory system SMD < 0.0001 0.54 (0.47 - 0.62) 278 12600
250.22 Type 2 diabetes with renal manifestations endocrine/metabolic SMD < 0.0001 0.49 (0.41 - 0.58) 195 14747
304 Adjustment reaction mental disorders SMD < 0.0001 0.59 (0.53 - 0.67) 367 14160
275.53 Disorders of phosphorus metabolism endocrine/metabolic SMD < 0.0001 0.42 (0.34 - 0.51) 110 16968
285.22 Anemia in neoplastic disease hematopoietic SMI < 0.0001 0.54 (0.47 - 0.63) 198 14706
585.33 Chronic Kidney Disease, Stage III genitourinary SMD < 0.0001 0.54 (0.47 - 0.63) 300 14818
578.9 Hemorrhage of gastrointestinal tract digestive SMD < 0.0001 0.64 (0.58 - 0.71) 538 15478
457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin circulatory system SMD < 0.0001 0.67 (0.61 - 0.74) 706 15238
338.1 Acute pain neurological SMD < 0.0001 0.73 (0.68 - 0.79) 1142 15503
578.9 Hemorrhage of gastrointestinal tract digestive SMI < 0.0001 0.68 (0.62 - 0.74) 538 15485
977 Personal history of allergy to medicinal agents injuries & poisonings SMD < 0.0001 0.63 (0.56 - 0.70) 460 15985
427.2 Atrial fibrillation and flutter circulatory system SMI < 0.0001 0.72 (0.67 - 0.78) 1234 12606
038.1 Gram negative septicemia infectious diseases SMD < 0.0001 0.50 (0.43 - 0.60) 204 15348
204.1 Lymphoid leukemia neoplasms SMD < 0.0001 0.49 (0.41 - 0.58) 159 16677
575 Other biliary tract disease digestive SMD < 0.0001 0.74 (0.68 - 0.79) 1119 15841
506 Empyema and pneumothorax respiratory SMI < 0.0001 0.60 (0.53 - 0.68) 267 15349
737 Curvature of spine musculoskeletal SMI < 0.0001 0.47 (0.39 - 0.57) 109 17330
008.5 Bacterial enteritis infectious diseases SMI < 0.0001 0.65 (0.58 - 0.72) 373 17040
960 Poisoning by antibiotics injuries & poisonings SMD < 0.0001 0.69 (0.63 - 0.75) 697 15985
280 Iron deficiency anemias hematopoietic SMD < 0.0001 0.70 (0.64 - 0.77) 822 14700
197 Chemotherapy neoplasms SMD < 0.0001 0.77 (0.72 - 0.82) 1450 14136
112 Candidiasis infectious diseases SMD < 0.0001 0.61 (0.54 - 0.69) 370 16933
286 Coagulation defects hematopoietic SMD < 0.0001 0.65 (0.58 - 0.72) 476 16143
530 Diseases of esophagus digestive SMD < 0.0001 0.81 (0.76 - 0.85) 2393 14896
710.19 Unspecified osteomyelitis musculoskeletal SMD < 0.0001 0.45 (0.36 - 0.55) 122 17063
287.3 Thrombocytopenia hematopoietic SMI < 0.0001 0.70 (0.64 - 0.77) 592 16149
994.1 Systemic inflammatory response syndrome (SIRS) injuries & poisonings SMD < 0.0001 0.46 (0.38 - 0.56) 135 15963
198.4 Secondary malignant neoplasm of liver neoplasms SMD < 0.0001 0.71 (0.65 - 0.77) 789 14136
272.1 Hyperlipidemia endocrine/metabolic SMD < 0.0001 0.81 (0.77 - 0.86) 2873 14755
457.3 Encounter for long-term (current) use of aspirin circulatory system SMD < 0.0001 0.66 (0.60 - 0.73) 581 15238
573 Other disorders of liver digestive SMI < 0.0001 0.74 (0.68 - 0.80) 830 13915
272 Disorders of lipoid metabolism endocrine/metabolic SMD < 0.0001 0.81 (0.77 - 0.86) 2884 14755
255 Disorders of adrenal glands endocrine/metabolic SMD < 0.0001 0.57 (0.49 - 0.66) 260 16932
080 Postoperative infection infectious diseases SMD < 0.0001 0.57 (0.50 - 0.66) 257 17208
250 Diabetes mellitus endocrine/metabolic SMI < 0.0001 1.21 (1.15 - 1.27) 2395 14753
426.92 Cardiac defibrillator in situ circulatory system SMD < 0.0001 0.45 (0.36 - 0.55) 125 12600
851 Complications of transplants and reattached limbs injuries & poisonings SMD < 0.0001 0.44 (0.36 - 0.55) 104 16969
401.3 Other hypertensive complications circulatory system SMD < 0.0001 0.47 (0.39 - 0.57) 139 13217
411.2 Myocardial infarction circulatory system SMD < 0.0001 0.62 (0.55 - 0.70) 423 16264
345 Epilepsy, recurrent seizures, convulsions neurological SMI < 0.0001 0.66 (0.59 - 0.73) 379 16355
426.91 Cardiac pacemaker in situ circulatory system SMD < 0.0001 0.50 (0.42 - 0.60) 211 12600
797 Shock symptoms SMD < 0.0001 0.50 (0.42 - 0.60) 160 17479
573.5 Jaundice (not of newborn) digestive SMD < 0.0001 0.60 (0.53 - 0.69) 331 13909
573.2 Liver replaced by transplant digestive SMD < 0.0001 0.51 (0.43 - 0.60) 165 13909
571.81 Portal hypertension digestive SMD < 0.0001 0.60 (0.53 - 0.68) 319 13909
287 Purpura and other hemorrhagic conditions hematopoietic SMI < 0.0001 0.72 (0.66 - 0.78) 617 16149
427.21 Atrial fibrillation circulatory system SMI < 0.0001 0.74 (0.68 - 0.80) 1180 12606
586 Other disorders of the kidney and ureters genitourinary SMD < 0.0001 0.72 (0.66 - 0.78) 857 14818
790.6 Other abnormal blood chemistry symptoms SMD < 0.0001 0.72 (0.66 - 0.78) 829 16690
117 Mycoses infectious diseases SMI < 0.0001 0.58 (0.51 - 0.67) 189 16940
568.1 Peritoneal adhesions (postoperative) (postinfection) digestive SMD < 0.0001 0.57 (0.50 - 0.66) 259 14829
275.3 Disorders of magnesium metabolism endocrine/metabolic SMI < 0.0001 0.61 (0.54 - 0.70) 253 16974
495 Asthma respiratory SMD < 0.0001 0.72 (0.66 - 0.78) 788 16322
550.6 Incisional hernia digestive SMD < 0.0001 0.54 (0.46 - 0.64) 200 16378
536 Disorders of function of stomach digestive SMI < 0.0001 0.71 (0.65 - 0.78) 554 16078
286.7 Other and unspecified coagulation defects hematopoietic SMD < 0.0001 0.53 (0.45 - 0.63) 178 16143
558 Noninfectious gastroenteritis digestive SMI < 0.0001 0.75 (0.69 - 0.81) 802 11805
327 Sleep disorders neurological SMD < 0.0001 0.74 (0.68 - 0.80) 941 15923
260.2 severe protein-calorie malnutrition endocrine/metabolic SMD < 0.0001 0.62 (0.55 - 0.71) 352 15668
275.5 Disorders of calcium/phosphorus metabolism endocrine/metabolic SMI < 0.0001 0.59 (0.52 - 0.68) 213 16974
433 Cerebrovascular disease circulatory system SMD < 0.0001 0.71 (0.65 - 0.78) 760 16754
743 Osteoporosis, osteopenia and pathological fracture musculoskeletal SMI < 0.0001 0.72 (0.66 - 0.79) 728 16918
851 Complications of transplants and reattached limbs injuries & poisonings SMI < 0.0001 0.52 (0.44 - 0.62) 104 16976
041.12 Methicillin resistant Staphylococcus aureus infectious diseases SMD < 0.0001 0.45 (0.36 - 0.55) 113 15348
550.5 Ventral hernia digestive SMI < 0.0001 1.46 (1.32 - 1.61) 431 16384
038.1 Gram negative septicemia infectious diseases SMI < 0.0001 0.58 (0.50 - 0.67) 204 15355
561 Symptoms involving digestive system digestive SMD < 0.0001 0.80 (0.76 - 0.85) 1959 11799
345.1 Epilepsy neurological SMD < 0.0001 0.49 (0.41 - 0.60) 136 16348
532 Dysphagia digestive SMI < 0.0001 0.71 (0.65 - 0.78) 569 14903
575.1 Cholangitis digestive SMI < 0.0001 0.63 (0.56 - 0.72) 291 15847
575.8 Other disorders of biliary tract digestive SMI < 0.0001 0.71 (0.65 - 0.78) 558 15847
316 Substance addiction and disorders mental disorders SMD < 0.0001 0.66 (0.59 - 0.74) 443 15498
510 Other diseases of lung respiratory SMD < 0.0001 0.59 (0.51 - 0.68) 255 17327
530.11 GERD digestive SMD < 0.0001 0.80 (0.75 - 0.85) 1746 14896
276.11 Hyperosmolality and/or hypernatremia endocrine/metabolic SMI < 0.0001 0.50 (0.42 - 0.61) 110 15001
574 Cholelithiasis and cholecystitis digestive SMD < 0.0001 0.75 (0.70 - 0.82) 1049 15841
530.1 Esophagitis, GERD and related diseases digestive SMD < 0.0001 0.81 (0.77 - 0.86) 2098 14896
573.3 Hepatomegaly digestive SMD < 0.0001 0.56 (0.47 - 0.65) 201 13909
279.1 Immunity deficiency endocrine/metabolic SMI < 0.0001 0.56 (0.48 - 0.66) 141 17084
562 Diverticulosis and diverticulitis digestive SMI < 0.0001 1.25 (1.17 - 1.33) 1488 11805
501 Pneumonitis due to inhalation of food or vomitus respiratory SMD < 0.0001 0.53 (0.45 - 0.63) 192 15342
797 Shock symptoms SMI < 0.0001 0.57 (0.49 - 0.67) 160 17486
596 Other disorders of bladder genitourinary SMD < 0.0001 0.67 (0.60 - 0.75) 451 16521
550 Abdominal hernia digestive SMI < 0.0001 1.25 (1.18 - 1.33) 1262 16384
250.24 Type 2 diabetes with neurological manifestations endocrine/metabolic SMD < 0.0001 0.52 (0.43 - 0.63) 162 14747
573.4 Acute and subacute necrosis of liver digestive SMD < 0.0001 0.50 (0.41 - 0.60) 129 13909
345.3 Convulsions neurological SMD < 0.0001 0.56 (0.48 - 0.66) 205 16348
859 Complication due to other implant and internal device injuries & poisonings SMI < 0.0001 0.59 (0.51 - 0.68) 185 16976
512.9 Other dyspnea respiratory SMI < 0.0001 0.74 (0.68 - 0.81) 704 15037
569.2 Gastrointestinal complications digestive SMD < 0.0001 0.62 (0.55 - 0.71) 310 14829
250.42 Other abnormal glucose endocrine/metabolic SMD < 0.0001 0.69 (0.62 - 0.76) 547 14747
425 Cardiomyopathy circulatory system SMI < 0.0001 0.66 (0.59 - 0.74) 332 17109
592.1 Cystitis genitourinary SMD < 0.0001 0.69 (0.62 - 0.77) 543 15562
573.9 Abnormal serum enzyme levels digestive SMD < 0.0001 0.65 (0.58 - 0.74) 385 13909
244 Hypothyroidism endocrine/metabolic SMD < 0.0001 0.77 (0.72 - 0.83) 1245 16096
592 Cystitis and urethritis genitourinary SMD < 0.0001 0.69 (0.63 - 0.77) 555 15562
275.53 Disorders of phosphorus metabolism endocrine/metabolic SMI < 0.0001 0.53 (0.45 - 0.64) 110 16974
008.52 Intestinal infection due to C. difficile infectious diseases SMD < 0.0001 0.63 (0.55 - 0.72) 314 17033
510 Other diseases of lung respiratory SMI < 0.0001 0.64 (0.56 - 0.73) 255 17334
426.2 Atrioventricular [AV] block circulatory system SMD < 0.0001 0.54 (0.46 - 0.65) 203 12600
157 Pancreatic cancer neoplasms SMI < 0.0001 0.69 (0.62 - 0.77) 440 15030
686 Other local infections of skin and subcutaneous tissue dermatologic SMD < 0.0001 0.48 (0.39 - 0.60) 114 16721
041.12 Methicillin resistant Staphylococcus aureus infectious diseases SMI < 0.0001 0.53 (0.45 - 0.64) 113 15355
426.32 Left bundle branch block circulatory system SMD < 0.0001 0.57 (0.48 - 0.67) 239 12600
427.61 Supraventricular premature beats circulatory system SMI < 0.0001 0.55 (0.46 - 0.65) 191 12606
587 Kidney replaced by transpant genitourinary SMD < 0.0001 0.51 (0.42 - 0.62) 138 14818
153 Colorectal cancer neoplasms SMI < 0.0001 0.78 (0.73 - 0.84) 1002 14717
496 Chronic airway obstruction respiratory SMD < 0.0001 0.70 (0.63 - 0.78) 577 16322
564 Functional digestive disorders digestive SMI < 0.0001 0.78 (0.72 - 0.84) 929 11805
204.2 Myeloid leukemia neoplasms SMD < 0.0001 0.58 (0.50 - 0.68) 213 16677
280.2 Iron deficiency anemia secondary to blood loss (chronic) hematopoietic SMI < 0.0001 0.66 (0.58 - 0.75) 307 14706
433.2 Occlusion of cerebral arteries circulatory system SMD < 0.0001 0.60 (0.52 - 0.70) 260 16754
244.4 Hypothyroidism NOS endocrine/metabolic SMD < 0.0001 0.77 (0.71 - 0.83) 1116 16096
426.8 Other cardiac conduction disorders circulatory system SMI < 0.0001 0.63 (0.55 - 0.72) 236 12606
081 Infection/inflammation of internal prosthetic device; implant; and graft infectious diseases SMI < 0.0001 0.61 (0.53 - 0.71) 181 17215
960.2 Allergy/adverse effect of penicillin injuries & poisonings SMD < 0.0001 0.66 (0.59 - 0.75) 386 15985
433.21 Cerebral artery occlusion, with cerebral infarction circulatory system SMD < 0.0001 0.60 (0.52 - 0.70) 255 16754
571.8 Liver abscess and sequelae of chronic liver disease digestive SMI < 0.0001 0.75 (0.69 - 0.82) 661 13915
480.1 Bacterial pneumonia respiratory SMD < 0.0001 0.51 (0.42 - 0.62) 126 16737
573.9 Abnormal serum enzyme levels digestive SMI < 0.0001 0.70 (0.63 - 0.78) 386 13915
785 Abdominal pain symptoms SMI < 0.0001 1.12 (1.08 - 1.16) 11048 6598
277.4 Disorders of bilirubin excretion endocrine/metabolic SMI < 0.0001 0.59 (0.51 - 0.69) 157 17309
270.38 Other specified disorders of plasma protein metabolism endocrine/metabolic SMI < 0.0001 0.55 (0.46 - 0.66) 112 17328
008.5 Bacterial enteritis infectious diseases SMD < 0.0001 0.67 (0.59 - 0.76) 373 17033
315 Develomental delays and disorders mental disorders SMD < 0.0001 0.51 (0.41 - 0.63) 111 17444
428.4 Heart failure with preserved EF [Diastolic heart failure] circulatory system SMD < 0.0001 0.51 (0.42 - 0.63) 148 16703
782.3 Edema symptoms SMI < 0.0001 0.78 (0.72 - 0.84) 878 16734
250.4 Abnormal glucose endocrine/metabolic SMD < 0.0001 0.73 (0.66 - 0.80) 666 14747
270.38 Other specified disorders of plasma protein metabolism endocrine/metabolic SMD < 0.0001 0.50 (0.41 - 0.62) 112 17321
427.11 Paroxysmal supraventricular tachycardia circulatory system SMD < 0.0001 0.55 (0.46 - 0.66) 170 12600
429.1 Heart transplant/surgery circulatory system SMI < 0.0001 0.55 (0.46 - 0.66) 102 16709
537 Other disorders of stomach and duodenum digestive SMI < 0.0001 0.76 (0.70 - 0.83) 666 16078
628 Ovarian cyst genitourinary SMD < 0.0001 1.57 (1.37 - 1.81) 383 9271
960 Poisoning by antibiotics injuries & poisonings SMI < 0.0001 0.77 (0.71 - 0.83) 697 15992
198.6 Secondary malignancy of bone neoplasms SMD < 0.0001 0.70 (0.62 - 0.78) 446 14136
200 Myeloproliferative disease neoplasms SMD < 0.0001 0.63 (0.55 - 0.73) 266 16677
513 Respiratory abnormalities respiratory SMD < 0.0001 0.55 (0.46 - 0.66) 149 17490
041.1 Staphylococcus infections infectious diseases SMI < 0.0001 0.65 (0.56 - 0.74) 227 15355
270 Disorders of protein plasma/amino-acid transport and metabolism endocrine/metabolic SMD < 0.0001 0.59 (0.51 - 0.70) 200 17321
592.11 Acute cystitis genitourinary SMD < 0.0001 0.70 (0.62 - 0.78) 458 15562
280.1 Iron deficiency anemias, unspecified or not due to blood loss hematopoietic SMI < 0.0001 0.75 (0.69 - 0.82) 599 14706
204.21 Myeloid leukemia, acute neoplasms SMD < 0.0001 0.59 (0.50 - 0.69) 183 16677
008 Intestinal infection infectious diseases SMD < 0.0001 0.73 (0.67 - 0.81) 606 17033
151 Cancer of stomach neoplasms SMI < 0.0001 0.65 (0.57 - 0.74) 234 15030
286.7 Other and unspecified coagulation defects hematopoietic SMI < 0.0001 0.62 (0.54 - 0.73) 178 16149
550.4 Umbilical hernia digestive SMI < 0.0001 1.58 (1.37 - 1.83) 189 16384
590 Pyelonephritis genitourinary SMD < 0.0001 0.69 (0.62 - 0.78) 428 15562
286 Coagulation defects hematopoietic SMI < 0.0001 0.74 (0.67 - 0.81) 476 16149
585.32 End stage renal disease genitourinary SMI < 0.0001 0.68 (0.60 - 0.77) 293 14825
279.1 Immunity deficiency endocrine/metabolic SMD < 0.0001 0.56 (0.46 - 0.67) 141 17077
573.6 Nonspecific elevation of levels of transaminase or lactic acid dehydrogenase [LDH] digestive SMI < 0.0001 0.71 (0.63 - 0.79) 349 13915
426.21 First degree AV block circulatory system SMD < 0.0001 0.51 (0.42 - 0.64) 135 12600
345.1 Epilepsy neurological SMI < 0.0001 0.59 (0.50 - 0.70) 136 16355
276.6 Fluid overload endocrine/metabolic SMI < 0.0001 0.67 (0.59 - 0.76) 275 15001
963.1 Antineoplastic and immunosuppressive drugs causing adverse effects injuries & poisonings SMI < 0.0001 0.66 (0.58 - 0.76) 233 15992
253 Disorders of the pituitary gland and its hypothalamic control endocrine/metabolic SMD < 0.0001 0.50 (0.41 - 0.63) 103 16932
560 Intestinal obstruction without mention of hernia digestive SMD < 0.0001 0.82 (0.77 - 0.88) 1698 11799
198.1 Secondary malignancy of lymph nodes neoplasms SMI < 0.0001 0.76 (0.70 - 0.83) 612 14143
596.5 Functional disorders of bladder genitourinary SMD < 0.0001 0.60 (0.51 - 0.71) 198 16521
433.8 Late effects of cerebrovascular disease circulatory system SMD < 0.0001 0.53 (0.43 - 0.65) 132 16754
591 Urinary tract infection genitourinary SMI < 0.0001 0.82 (0.76 - 0.87) 1188 15566
274.1 Gout endocrine/metabolic SMD < 0.0001 0.58 (0.49 - 0.70) 184 17437
345.3 Convulsions neurological SMI < 0.0001 0.64 (0.56 - 0.74) 205 16355
963 Poisoning by primarily systemic agents injuries & poisonings SMI < 0.0001 0.67 (0.59 - 0.76) 238 15992
277.4 Disorders of bilirubin excretion endocrine/metabolic SMD < 0.0001 0.58 (0.48 - 0.69) 157 17303
280.2 Iron deficiency anemia secondary to blood loss (chronic) hematopoietic SMD < 0.0001 0.66 (0.57 - 0.75) 307 14700
540.11 Acute appendicitis digestive SMD < 0.0001 1.43 (1.27 - 1.61) 525 17039
270.3 Disorders of plasma protein metabolism endocrine/metabolic SMD < 0.0001 0.59 (0.50 - 0.70) 177 17321
550.6 Incisional hernia digestive SMI < 0.0001 1.54 (1.34 - 1.78) 200 16384
579.2 Splenomegaly digestive SMD < 0.0001 0.66 (0.58 - 0.76) 300 15478
420 Carditis circulatory system SMD < 0.0001 0.63 (0.54 - 0.73) 237 17102
425.1 Primary/intrinsic cardiomyopathies circulatory system SMI < 0.0001 0.68 (0.60 - 0.77) 278 17109
580 Nephritis; nephrosis; renal sclerosis genitourinary SMD < 0.0001 0.56 (0.46 - 0.68) 139 14818
427.1 Paroxysmal tachycardia, unspecified circulatory system SMI < 0.0001 0.66 (0.58 - 0.76) 278 12606
585.3 Chronic renal failure [CKD] genitourinary SMI < 0.0001 0.78 (0.72 - 0.85) 828 14825
274 Gout and other crystal arthropathies endocrine/metabolic SMD < 0.0001 0.60 (0.51 - 0.71) 202 17437
740 Osteoarthrosis musculoskeletal SMD < 0.0001 0.73 (0.66 - 0.81) 564 17075
990 Effects radiation NOS injuries & poisonings SMD < 0.0001 0.72 (0.65 - 0.81) 547 15569
250.1 Type 1 diabetes endocrine/metabolic SMD < 0.0001 0.57 (0.47 - 0.69) 147 14747
300.1 Anxiety disorder mental disorders SMI < 0.0001 0.83 (0.78 - 0.88) 1281 14166
578 Gastrointestinal hemorrhage digestive SMI < 0.0001 0.82 (0.77 - 0.88) 1127 15485
555.21 Ulcerative colitis (chronic) digestive SMI < 0.0001 0.61 (0.52 - 0.72) 135 11805
195.1 Malignant neoplasm, other neoplasms SMD < 0.0001 0.76 (0.69 - 0.83) 707 14136
255.2 Adrenal hypofunction endocrine/metabolic SMI < 0.0001 0.58 (0.49 - 0.70) 118 16939
255.21 Glucocorticoid deficiency endocrine/metabolic SMI < 0.0001 0.58 (0.49 - 0.70) 118 16939
349 Other and unspecified disorders of the nervous system neurological SMD < 0.0001 0.51 (0.41 - 0.64) 104 16348
415 Pulmonary heart disease circulatory system SMI < 0.0001 0.79 (0.73 - 0.85) 770 16494
743.1 Osteoporosis musculoskeletal SMI < 0.0001 0.70 (0.63 - 0.79) 407 16918
198.3 Secondary malignant neoplasm of digestive systems neoplasms SMD < 0.0001 0.75 (0.68 - 0.83) 653 14136
411.8 Other chronic ischemic heart disease, unspecified circulatory system SMD < 0.0001 0.50 (0.40 - 0.64) 103 16264
426.9 Cardiac pacemaker/device in situ circulatory system SMI < 0.0001 0.67 (0.58 - 0.76) 313 12606
506 Empyema and pneumothorax respiratory SMD < 0.0001 0.65 (0.56 - 0.75) 267 15342
204 Leukemia neoplasms SMI < 0.0001 0.74 (0.67 - 0.82) 440 16684
595 Hydronephrosis genitourinary SMI < 0.0001 0.78 (0.72 - 0.85) 680 16294
573.6 Nonspecific elevation of levels of transaminase or lactic acid dehydrogenase [LDH] digestive SMD < 0.0001 0.69 (0.60 - 0.78) 349 13909
977 Personal history of allergy to medicinal agents injuries & poisonings SMI < 0.0001 0.75 (0.68 - 0.82) 460 15992
280.1 Iron deficiency anemias, unspecified or not due to blood loss hematopoietic SMD < 0.0001 0.74 (0.67 - 0.82) 599 14700
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus neoplasms SMI < 0.0001 0.76 (0.69 - 0.83) 506 14717
509.8 Dependence on respirator [Ventilator] or supplemental oxygen respiratory SMI < 0.0001 0.59 (0.49 - 0.71) 119 15349
860 Bone marrow or stem cell transplant neoplasms SMI < 0.0001 0.68 (0.59 - 0.77) 216 17430
270 Disorders of protein plasma/amino-acid transport and metabolism endocrine/metabolic SMI < 0.0001 0.65 (0.57 - 0.76) 200 17328
772.3 Muscle weakness symptoms SMI < 0.0001 0.69 (0.60 - 0.78) 266 17215
577.1 Acute pancreatitis digestive SMD < 0.0001 0.73 (0.66 - 0.82) 495 16514
285.21 Anemia in chronic kidney disease hematopoietic SMI < 0.0001 0.64 (0.55 - 0.75) 178 14706
740.1 Osteoarthritis; localized musculoskeletal SMI < 0.0001 1.42 (1.26 - 1.60) 318 17082
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum neoplasms SMI < 0.0001 0.77 (0.71 - 0.85) 627 15030
112 Candidiasis infectious diseases SMI < 0.0001 0.73 (0.66 - 0.82) 370 16940
565 Anal and rectal conditions digestive SMI < 0.0001 0.77 (0.71 - 0.85) 541 14836
577 Diseases of pancreas digestive SMD < 0.0001 0.81 (0.75 - 0.87) 1125 16514
574.1 Cholelithiasis digestive SMD < 0.0001 0.78 (0.71 - 0.85) 783 15841
562.2 Diverticulitis digestive SMI < 0.0001 1.26 (1.16 - 1.36) 755 11805
153.2 Colon cancer neoplasms SMI < 0.0001 0.79 (0.72 - 0.86) 695 14717
575.7 Other disorders of gallbladder digestive SMD < 0.0001 0.62 (0.53 - 0.74) 192 15841
575.2 Obstruction of bile duct digestive SMD < 0.0001 0.72 (0.64 - 0.81) 412 15841
696.4 Psoriasis dermatologic SMD < 0.0001 0.54 (0.43 - 0.67) 106 16759
249 Secondary diabetes mellitus endocrine/metabolic SMD < 0.0001 0.60 (0.50 - 0.72) 164 14747
327.6 Circadian rhythm sleep disorder neurological SMI < 0.0001 0.60 (0.50 - 0.72) 118 15928
743.11 Osteoporosis NOS musculoskeletal SMI < 0.0001 0.71 (0.63 - 0.80) 384 16918
270.3 Disorders of plasma protein metabolism endocrine/metabolic SMI < 0.0001 0.64 (0.55 - 0.75) 177 17328
428.3 Heart failure with reduced EF [Systolic or combined heart failure] circulatory system SMI < 0.0001 0.73 (0.66 - 0.82) 414 16709
560.3 Peritoneal or intestinal adhesions digestive SMI < 0.0001 0.62 (0.52 - 0.73) 142 11805
349 Other and unspecified disorders of the nervous system neurological SMI < 0.0001 0.58 (0.48 - 0.71) 104 16355
357 Inflammatory and toxic neuropathy neurological SMD < 0.0001 0.62 (0.52 - 0.74) 179 17286
443 Peripheral vascular disease circulatory system SMD < 0.0001 0.64 (0.55 - 0.75) 226 16717
415.1 Acute pulmonary heart disease circulatory system SMI < 0.0001 0.74 (0.66 - 0.82) 394 16494
495 Asthma respiratory SMI < 0.0001 1.23 (1.14 - 1.33) 788 16329
355.1 Chronic pain syndrome neurological SMD < 0.0001 0.60 (0.50 - 0.72) 148 17138
532 Dysphagia digestive SMD < 0.0001 0.75 (0.68 - 0.84) 569 14896
963 Poisoning by primarily systemic agents injuries & poisonings SMD 0.00011 0.66 (0.57 - 0.77) 238 15985
204.1 Lymphoid leukemia neoplasms SMI 0.00011 0.65 (0.56 - 0.76) 159 16684
564 Functional digestive disorders digestive SMD 0.00012 0.80 (0.74 - 0.87) 929 11799
540.1 Appendicitis digestive SMD 0.00012 1.36 (1.21 - 1.52) 567 17039
415.11 Pulmonary embolism and infarction, acute circulatory system SMI 0.00012 0.74 (0.66 - 0.83) 392 16494
079 Viral infection infectious diseases SMI 0.00013 0.72 (0.64 - 0.81) 283 16473
396 Abnormal heart sounds circulatory system SMD 0.00014 0.54 (0.43 - 0.68) 102 17028
540 Appendiceal conditions digestive SMD 0.00016 1.34 (1.20 - 1.50) 600 17039
459 Other disorders of circulatory system circulatory system SMD 0.00016 0.70 (0.61 - 0.80) 316 16641
427.11 Paroxysmal supraventricular tachycardia circulatory system SMI 0.00016 0.63 (0.53 - 0.75) 170 12606
578 Gastrointestinal hemorrhage digestive SMD 0.00016 0.82 (0.76 - 0.88) 1127 15478
796 Elevated prostate specific antigen [PSA] genitourinary SMI 0.00018 1.84 (1.47 - 2.31) 108 6261
696 Psoriasis and related disorders dermatologic SMD 0.00018 0.56 (0.46 - 0.70) 112 16759
963.1 Antineoplastic and immunosuppressive drugs causing adverse effects injuries & poisonings SMD 0.00019 0.66 (0.57 - 0.77) 233 15985
300 Anxiety disorders mental disorders SMI 0.00023 0.86 (0.81 - 0.91) 1502 14166
710 Osteomyelitis, periostitis, and other infections involving bone musculoskeletal SMI 0.00023 0.64 (0.54 - 0.76) 155 17069
285.22 Anemia in neoplastic disease hematopoietic SMD 0.00023 0.63 (0.54 - 0.75) 198 14700
198.2 Secondary malignancy of respiratory organs neoplasms SMD 0.00023 0.73 (0.65 - 0.82) 408 14136
454 Varicose veins circulatory system SMD 0.00028 0.60 (0.50 - 0.73) 145 15238
596 Other disorders of bladder genitourinary SMI 0.00029 0.76 (0.69 - 0.85) 451 16528
562.1 Diverticulosis digestive SMI 0.00031 1.23 (1.14 - 1.33) 886 11805
433.31 Transient cerebral ischemia circulatory system SMD 0.00031 0.71 (0.62 - 0.81) 358 16754
771 Musculoskeletal symptoms referable to limbs symptoms SMD 0.00032 0.63 (0.53 - 0.75) 177 17137
571.5 Other chronic nonalcoholic liver disease digestive SMI 0.00032 1.17 (1.10 - 1.24) 1386 13915
710.1 Osteomyelitis musculoskeletal SMI 0.00034 0.64 (0.55 - 0.76) 154 17069
433.3 Cerebral ischemia circulatory system SMD 0.00036 0.72 (0.63 - 0.81) 377 16754
502 Postinflammatory pulmonary fibrosis respiratory SMD 0.00037 0.58 (0.47 - 0.72) 128 15342
189.1 Cancer of kidney and renal pelvis neoplasms SMI 0.00046 1.40 (1.23 - 1.59) 275 17039
428 Congestive heart failure; nonhypertensive circulatory system SMI 0.00047 0.81 (0.75 - 0.88) 821 16709
427.12 Paroxysmal ventricular tachycardia circulatory system SMD 0.00048 0.54 (0.43 - 0.69) 101 12600
459 Other disorders of circulatory system circulatory system SMI 0.00060 0.74 (0.65 - 0.83) 317 16647
596.5 Functional disorders of bladder genitourinary SMI 0.00063 0.68 (0.59 - 0.79) 198 16528
578.1 Hematemesis digestive SMD 0.00065 0.59 (0.48 - 0.73) 126 15478
327 Sleep disorders neurological SMI 0.00068 0.83 (0.77 - 0.89) 943 15928
459.9 Circulatory disease NEC circulatory system SMD 0.00071 0.59 (0.48 - 0.72) 124 16641
771.1 Swelling of limb symptoms SMD 0.00078 0.71 (0.62 - 0.81) 308 17137
276.13 Hyperpotassemia endocrine/metabolic SMI 0.00082 0.68 (0.59 - 0.79) 202 15001
327.4 Insomnia neurological SMI 0.00085 0.80 (0.73 - 0.87) 619 15928
260.3 Adult failure to thrive endocrine/metabolic SMD 0.00086 0.68 (0.58 - 0.79) 244 15668
427.5 Arrhythmia (cardiac) NOS circulatory system SMD 0.00087 0.58 (0.47 - 0.72) 124 12600
740.11 Osteoarthrosis, localized, primary musculoskeletal SMI 0.00092 1.40 (1.22 - 1.59) 274 17082
289.5 Diseases of spleen hematopoietic SMD 0.00097 0.63 (0.53 - 0.76) 163 15441
577 Diseases of pancreas digestive SMI 0.0013 0.85 (0.79 - 0.91) 1125 16521
333 Extrapyramidal disease and abnormal movement disorders neurological SMI 0.0014 0.62 (0.52 - 0.76) 126 16355
559 Ileostomy status digestive SMD 0.0015 0.70 (0.61 - 0.81) 267 11799
418 Nonspecific chest pain circulatory system SMD 0.0015 0.85 (0.79 - 0.91) 1424 16206
568 Other disorders of peritoneum digestive SMI 0.0016 0.80 (0.73 - 0.87) 548 14836
296.1 Bipolar mental disorders SMD 0.0016 0.69 (0.59 - 0.80) 249 14160
430 Intracranial hemorrhage circulatory system SMD 0.0016 0.67 (0.57 - 0.79) 207 16754
625 Pain and other symptoms associated with female genital organs genitourinary SMD 0.0017 1.41 (1.23 - 1.62) 366 9710
427.5 Arrhythmia (cardiac) NOS circulatory system SMI 0.0018 0.62 (0.51 - 0.75) 124 12606
348.2 Cerebral edema and compression of brain neurological SMD 0.0018 0.59 (0.47 - 0.73) 112 16348
430 Intracranial hemorrhage circulatory system SMI 0.0020 0.70 (0.60 - 0.81) 207 16761
729 Other disorders of soft tissues musculoskeletal SMD 0.0021 0.68 (0.58 - 0.80) 227 16966
740 Osteoarthrosis musculoskeletal SMI 0.0022 1.26 (1.15 - 1.39) 564 17082
459.9 Circulatory disease NEC circulatory system SMI 0.0026 0.64 (0.53 - 0.77) 125 16647
870 Open wounds of head; neck; and trunk injuries & poisonings SMD 0.0026 0.71 (0.62 - 0.82) 275 17221
789 Nausea and vomiting symptoms SMD 0.0027 0.90 (0.86 - 0.94) 4547 13092
577.2 Chronic pancreatitis digestive SMD 0.0030 0.66 (0.56 - 0.79) 178 16514
710.19 Unspecified osteomyelitis musculoskeletal SMI 0.0031 0.64 (0.53 - 0.77) 122 17069
426.3 Bundle branch block circulatory system SMI 0.0032 0.77 (0.69 - 0.86) 539 12606
315 Develomental delays and disorders mental disorders SMI 0.0035 0.64 (0.53 - 0.77) 111 17451
771 Musculoskeletal symptoms referable to limbs symptoms SMI 0.0036 0.68 (0.59 - 0.80) 177 17144
740.1 Osteoarthritis; localized musculoskeletal SMD 0.0036 0.72 (0.63 - 0.83) 318 17075
287.31 Primary thrombocytopenia hematopoietic SMD 0.0036 0.59 (0.48 - 0.74) 110 16143
594 Urinary calculus genitourinary SMI 0.0037 1.19 (1.10 - 1.27) 883 16294
165 Cancer within the respiratory system neoplasms SMI 0.0037 0.71 (0.61 - 0.82) 233 17403
528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue digestive SMI 0.0037 0.68 (0.58 - 0.80) 161 17385
427.22 Atrial flutter circulatory system SMI 0.0040 0.69 (0.59 - 0.81) 235 12606
189.11 Malignant neoplasm of kidney, except pelvis neoplasms SMI 0.0041 1.41 (1.22 - 1.62) 220 17039
290.1 Dementias mental disorders SMI 0.0046 0.69 (0.59 - 0.81) 312 16104
994.1 Systemic inflammatory response syndrome (SIRS) injuries & poisonings SMI 0.0047 0.66 (0.55 - 0.79) 135 15970
202 Cancer of other lymphoid, histiocytic tissue neoplasms SMD 0.0050 0.75 (0.66 - 0.85) 391 16677
218 Benign neoplasm of uterus neoplasms SMI 0.0055 1.28 (1.15 - 1.41) 384 8968
443.9 Peripheral vascular disease, unspecified circulatory system SMD 0.0055 0.65 (0.54 - 0.78) 177 16717
512.8 Cough respiratory SMD 0.0069 0.81 (0.75 - 0.89) 806 15031
165.1 Cancer of bronchus; lung neoplasms SMI 0.0074 0.71 (0.61 - 0.82) 225 17403
594.1 Calculus of kidney genitourinary SMI 0.0077 1.20 (1.11 - 1.30) 694 16294
395.6 Heart valve replaced circulatory system SMD 0.0081 0.62 (0.51 - 0.77) 138 17028
871 Open wounds of extremities injuries & poisonings SMD 0.0082 0.65 (0.54 - 0.79) 152 17221
200 Myeloproliferative disease neoplasms SMI 0.0086 0.74 (0.65 - 0.84) 266 16684
292.1 Aphasia/speech disturbance mental disorders SMD 0.010 0.63 (0.51 - 0.77) 139 16099
595 Hydronephrosis genitourinary SMD 0.011 0.81 (0.74 - 0.89) 680 16288
271 Disorders of carbohydrate transport and metabolism endocrine/metabolic SMI 0.011 1.53 (1.26 - 1.84) 116 17530
714.1 Rheumatoid arthritis musculoskeletal SMD 0.012 0.67 (0.56 - 0.80) 184 17185
271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption endocrine/metabolic SMI 0.012 1.54 (1.27 - 1.85) 113 17530
859 Complication due to other implant and internal device injuries & poisonings SMD 0.012 0.68 (0.57 - 0.81) 185 16969
530.2 Esophageal bleeding (varices/hemorrhage) digestive SMD 0.014 0.70 (0.60 - 0.82) 225 14896
575.8 Other disorders of biliary tract digestive SMD 0.014 0.79 (0.71 - 0.88) 558 15841
306 Other mental disorder mental disorders SMD 0.014 0.74 (0.64 - 0.85) 317 14160
585.31 Renal dialysis genitourinary SMI 0.015 0.74 (0.64 - 0.84) 238 14825
939 Atopic/contact dermatitis due to other or unspecified dermatologic SMD 0.015 0.77 (0.68 - 0.87) 416 16743
218.1 Uterine leiomyoma neoplasms SMI 0.015 1.26 (1.14 - 1.40) 377 8968
136 Other infectious and parasitic diseases infectious diseases SMD 0.016 0.69 (0.59 - 0.82) 203 17387
689 Disorder of skin and subcutaneous tissue NOS dermatologic SMD 0.017 0.68 (0.57 - 0.81) 185 17454
805 Fracture of vertebral column without mention of spinal cord injury injuries & poisonings SMI 0.017 0.75 (0.66 - 0.85) 283 16757
714 Rheumatoid arthritis and other inflammatory polyarthropathies musculoskeletal SMD 0.017 0.69 (0.59 - 0.82) 212 17185
420 Carditis circulatory system SMI 0.017 0.74 (0.64 - 0.85) 237 17109
182 Malignant neoplasm of uterus neoplasms SMD 0.017 0.72 (0.62 - 0.83) 268 8577
185 Cancer of prostate neoplasms SMI 0.018 1.30 (1.16 - 1.47) 483 6261
965 Poisoning by analgesics, antipyretics, and antirheumatics injuries & poisonings SMD 0.019 0.66 (0.55 - 0.80) 164 15985
772.3 Muscle weakness symptoms SMD 0.019 0.72 (0.63 - 0.84) 266 17208
189 Cancer of urinary organs (incl. kidney and bladder) neoplasms SMI 0.021 1.23 (1.12 - 1.35) 607 17039
536.7 Complications of gastrostomy, colostomy and enterostomy digestive SMD 0.021 0.64 (0.53 - 0.79) 132 16072
745 Pain in joint musculoskeletal SMI 0.021 1.13 (1.07 - 1.20) 1533 16113
531 Peptic ulcer (excl. esophageal) digestive SMI 0.023 0.79 (0.71 - 0.88) 410 17236
740.11 Osteoarthrosis, localized, primary musculoskeletal SMD 0.024 0.72 (0.62 - 0.84) 274 17075
587 Kidney replaced by transpant genitourinary SMI 0.025 0.69 (0.58 - 0.82) 138 14825
512 Other symptoms of respiratory system respiratory SMI 0.026 0.91 (0.87 - 0.95) 2609 15037
458.1 Orthostatic hypotension circulatory system SMI 0.029 0.65 (0.53 - 0.80) 109 16647
426.31 Right bundle branch block circulatory system SMI 0.031 0.72 (0.62 - 0.84) 265 12606
579 Other symptoms involving abdomen and pelvis digestive SMD 0.031 0.84 (0.77 - 0.91) 932 15478
709 Diffuse diseases of connective tissue dermatologic SMD 0.031 0.67 (0.55 - 0.81) 156 16820
573.2 Liver replaced by transplant digestive SMI 0.031 0.71 (0.60 - 0.83) 165 13915
277 Other disorders of metabolism endocrine/metabolic SMI 0.032 0.68 (0.57 - 0.82) 128 17309
289.4 Lymphadenitis hematopoietic SMD 0.035 0.83 (0.75 - 0.90) 766 15441
764 Sciatica symptoms SMD 0.035 0.72 (0.62 - 0.84) 240 17093
202 Cancer of other lymphoid, histiocytic tissue neoplasms SMI 0.036 0.79 (0.71 - 0.88) 391 16684
574.3 Cholecystitis without cholelithiasis digestive SMD 0.037 0.76 (0.66 - 0.86) 334 15841
348.9 Other conditions of brain, NOS neurological SMI 0.038 0.68 (0.57 - 0.82) 139 16355
536.3 Gastroparesis digestive SMI 0.038 0.76 (0.66 - 0.86) 239 16078
599.4 Urinary incontinence genitourinary SMD 0.040 0.74 (0.64 - 0.85) 282 15860
789 Nausea and vomiting symptoms SMI 0.040 0.93 (0.89 - 0.96) 4547 13099
496.2 Chronic bronchitis respiratory SMD 0.040 0.63 (0.51 - 0.79) 122 16322
394 Rheumatic disease of the heart valves circulatory system SMD 0.042 0.63 (0.51 - 0.79) 123 17028
853 Complication of colostomy or enterostomy injuries & poisonings SMI 0.043 0.66 (0.54 - 0.80) 102 16976
519 Other diseases of respiratory system, not elsewhere classified respiratory SMI 0.043 0.76 (0.67 - 0.87) 262 17375
577.2 Chronic pancreatitis digestive SMI 0.045 0.73 (0.63 - 0.85) 178 16521
426.92 Cardiac defibrillator in situ circulatory system SMI 0.048 0.66 (0.55 - 0.81) 125 12606
420.2 Pericarditis circulatory system SMI 0.055 0.71 (0.60 - 0.84) 163 17109
428.1 Congestive heart failure (CHF) NOS circulatory system SMI 0.061 0.80 (0.72 - 0.89) 435 16709
272.11 Hypercholesterolemia endocrine/metabolic SMI 0.063 1.30 (1.14 - 1.47) 310 14762
519 Other diseases of respiratory system, not elsewhere classified respiratory SMD 0.064 0.74 (0.64 - 0.86) 262 17368
575.7 Other disorders of gallbladder digestive SMI 0.067 0.73 (0.63 - 0.85) 192 15847
687.1 Rash and other nonspecific skin eruption dermatologic SMD 0.068 0.78 (0.70 - 0.88) 417 16831
338.1 Acute pain neurological SMI 0.068 0.88 (0.82 - 0.93) 1143 15508
277 Other disorders of metabolism endocrine/metabolic SMD 0.071 0.66 (0.53 - 0.81) 127 17303
599.2 Retention of urine genitourinary SMI 0.074 0.80 (0.72 - 0.89) 440 15864
429 Ill-defined descriptions and complications of heart disease circulatory system SMD 0.079 0.64 (0.52 - 0.80) 116 16703
574.2 Calculus of bile duct digestive SMD 0.083 0.72 (0.61 - 0.85) 222 15841
289 Other diseases of blood and blood-forming organs hematopoietic SMI 0.085 0.73 (0.62 - 0.85) 174 15447
204.2 Myeloid leukemia neoplasms SMI 0.085 0.75 (0.65 - 0.86) 213 16684
170 Cancer of bone and connective tissue neoplasms SMI 0.10 0.78 (0.69 - 0.88) 300 17346
550.2 Diaphragmatic hernia digestive SMD 0.10 0.77 (0.67 - 0.88) 343 16378
300.9 Posttraumatic stress disorder mental disorders SMD 0.10 0.63 (0.51 - 0.80) 106 14160
204.21 Myeloid leukemia, acute neoplasms SMI 0.10 0.74 (0.63 - 0.86) 183 16684
295 Schizophrenia and other psychotic disorders mental disorders SMD 0.11 0.70 (0.59 - 0.84) 184 14160
592.1 Cystitis genitourinary SMI 0.11 0.82 (0.75 - 0.91) 544 15566
536.3 Gastroparesis digestive SMD 0.11 0.73 (0.63 - 0.86) 238 16072
189 Cancer of urinary organs (incl. kidney and bladder) neoplasms SMD 0.12 0.82 (0.74 - 0.90) 607 17032
070.2 Viral hepatitis B infectious diseases SMD 0.12 1.45 (1.20 - 1.74) 191 16466
689 Disorder of skin and subcutaneous tissue NOS dermatologic SMI 0.13 0.74 (0.63 - 0.86) 185 17461
960.2 Allergy/adverse effect of penicillin injuries & poisonings SMI 0.14 0.80 (0.72 - 0.90) 386 15992
070.2 Viral hepatitis B infectious diseases SMI 0.14 0.74 (0.63 - 0.86) 191 16473
286.2 Encounter for long-term (current) use of anticoagulants hematopoietic SMI 0.15 0.84 (0.77 - 0.92) 636 16149
155 Cancer of liver and intrahepatic bile duct neoplasms SMI 0.15 0.80 (0.72 - 0.90) 391 15030
198.1 Secondary malignancy of lymph nodes neoplasms SMD 0.15 0.82 (0.75 - 0.91) 612 14136
592 Cystitis and urethritis genitourinary SMI 0.16 0.83 (0.75 - 0.91) 556 15566
281 Other deficiency anemia hematopoietic SMI 0.16 0.68 (0.55 - 0.83) 121 14706
080 Postoperative infection infectious diseases SMI 0.17 0.78 (0.68 - 0.88) 257 17215
600 Hyperplasia of prostate genitourinary SMI 0.18 1.25 (1.11 - 1.39) 539 6261
599 Other symptoms/disorders or the urinary system genitourinary SMD 0.18 0.88 (0.82 - 0.94) 1478 15860
202.2 Non-Hodgkins lymphoma neoplasms SMD 0.19 0.77 (0.68 - 0.88) 334 16677
110 Dermatophytosis / Dermatomycosis infectious diseases SMD 0.19 0.73 (0.62 - 0.86) 216 16933
495.2 Asthma with exacerbation respiratory SMI 0.19 1.46 (1.20 - 1.78) 103 16329
070.3 Viral hepatitis C infectious diseases SMD 0.20 0.78 (0.69 - 0.89) 359 16466
870 Open wounds of head; neck; and trunk injuries & poisonings SMI 0.21 0.79 (0.69 - 0.89) 276 17226
770 Myalgia and myositis unspecified symptoms SMD 0.21 0.79 (0.70 - 0.90) 403 17236
136 Other infectious and parasitic diseases infectious diseases SMI 0.24 0.76 (0.65 - 0.88) 203 17394
850 Hemorrhage or hematoma complicating a procedure injuries & poisonings SMD 0.25 0.69 (0.57 - 0.84) 149 16969
709 Diffuse diseases of connective tissue dermatologic SMI 0.27 0.73 (0.62 - 0.86) 156 16827
054 Herpes simplex infectious diseases SMD 0.27 0.68 (0.56 - 0.84) 135 16466
420.2 Pericarditis circulatory system SMD 0.29 0.71 (0.59 - 0.85) 163 17102
740.9 Osteoarthrosis NOS musculoskeletal SMD 0.32 0.75 (0.65 - 0.88) 263 17075
512.7 Shortness of breath respiratory SMI 0.37 0.90 (0.85 - 0.95) 1556 15037
586.4 Stricture/obstruction of ureter genitourinary SMD 0.37 0.71 (0.59 - 0.85) 166 14818
272.13 Mixed hyperlipidemia endocrine/metabolic SMI 0.38 1.42 (1.17 - 1.72) 129 14762
289.5 Diseases of spleen hematopoietic SMI 0.40 0.74 (0.63 - 0.87) 163 15447
531 Peptic ulcer (excl. esophageal) digestive SMD 0.41 0.80 (0.71 - 0.91) 410 17229
575.1 Cholangitis digestive SMD 0.42 0.77 (0.67 - 0.89) 291 15841
695 Erythematous conditions dermatologic SMD 0.43 0.79 (0.69 - 0.90) 349 16949
558 Noninfectious gastroenteritis digestive SMD 0.49 0.85 (0.78 - 0.93) 802 11799
696.4 Psoriasis dermatologic SMI 0.50 1.43 (1.17 - 1.75) 106 16765
726 Peripheral enthesopathies and allied syndromes musculoskeletal SMI 0.51 1.29 (1.12 - 1.49) 218 16973
540.11 Acute appendicitis digestive SMI 0.52 1.17 (1.07 - 1.28) 525 17046
180 Cervical cancer and dysplasia neoplasms SMI 0.54 0.73 (0.62 - 0.87) 148 8566
979 Adverse drug events and drug allergies injuries & poisonings SMI 0.55 0.70 (0.58 - 0.86) 112 15992
261 Vitamin deficiency endocrine/metabolic SMD 0.58 0.82 (0.74 - 0.92) 517 15668
766 Neuralgia, neuritis, and radiculitis NOS symptoms SMD 0.59 0.72 (0.60 - 0.87) 162 17093
716.9 Arthropathy NOS musculoskeletal SMD 0.60 0.66 (0.53 - 0.84) 106 17063
788 Syncope and collapse symptoms SMI 0.60 0.82 (0.74 - 0.92) 400 17246
930 Allergic reaction to food injuries & poisonings SMI 0.60 0.72 (0.60 - 0.87) 127 16750
348.9 Other conditions of brain, NOS neurological SMD 0.61 0.69 (0.57 - 0.85) 139 16348
819 Skull and face fracture and other intercranial injury injuries & poisonings SMI 0.61 0.71 (0.59 - 0.86) 106 17494
592.11 Acute cystitis genitourinary SMI 0.62 0.83 (0.75 - 0.92) 459 15566
687 Symptoms affecting skin dermatologic SMD 0.66 0.70 (0.57 - 0.86) 133 16831
180.1 Cervical cancer neoplasms SMI 0.66 0.72 (0.60 - 0.87) 133 8566
916 Contusion injuries & poisonings SMD 0.68 0.78 (0.67 - 0.90) 276 17363
502 Postinflammatory pulmonary fibrosis respiratory SMI 0.68 0.71 (0.59 - 0.86) 128 15349
766 Neuralgia, neuritis, and radiculitis NOS symptoms SMI 0.72 0.75 (0.64 - 0.88) 162 17097
751 Genitourinary congenital anomalies congenital anomalies SMI 0.75 0.75 (0.63 - 0.88) 148 17411
573 Other disorders of liver digestive SMD 0.80 0.86 (0.79 - 0.94) 830 13909
261 Vitamin deficiency endocrine/metabolic SMI 0.83 0.84 (0.77 - 0.93) 518 15673
218.1 Uterine leiomyoma neoplasms SMD 0.85 1.26 (1.10 - 1.44) 377 8963
536 Disorders of function of stomach digestive SMD 0.86 0.84 (0.75 - 0.93) 553 16072
202.2 Non-Hodgkins lymphoma neoplasms SMI 0.88 0.81 (0.72 - 0.92) 334 16684
853 Complication of colostomy or enterostomy injuries & poisonings SMD 0.88 0.67 (0.54 - 0.85) 102 16969
627 Menopausal and postmenopausal disorders genitourinary SMI 0.89 1.25 (1.10 - 1.43) 255 9274
531.2 Gastric ulcer digestive SMI 0.90 0.72 (0.60 - 0.87) 125 17236
189.11 Malignant neoplasm of kidney, except pelvis neoplasms SMD 0.91 0.76 (0.64 - 0.89) 220 17032
450 Noninfectious disorders of lymphatic channels circulatory system SMD 0.92 0.69 (0.56 - 0.86) 119 17520
585.4 Chronic kidney disease, Stage I or II genitourinary SMD 0.93 0.66 (0.52 - 0.84) 102 14818
573.4 Acute and subacute necrosis of liver digestive SMI 0.96 0.73 (0.61 - 0.88) 129 13915
513 Respiratory abnormalities respiratory SMI 0.96 0.74 (0.62 - 0.88) 149 17497
743.9 Osteopenia or other disorder of bone and cartilage musculoskeletal SMI 0.99 0.79 (0.69 - 0.91) 265 16918
189.1 Cancer of kidney and renal pelvis neoplasms SMD 0.99 0.78 (0.67 - 0.90) 275 17032
170.2 Cancer of connective tissue neoplasms SMI 1.0 0.80 (0.70 - 0.91) 269 17346
441 Vascular insufficiency of intestine circulatory system SMI 1.0 0.78 (0.68 - 0.90) 228 16724
733 Other disorders of bone and cartilage musculoskeletal SMI 1.0 0.76 (0.65 - 0.90) 189 17069
686 Other local infections of skin and subcutaneous tissue dermatologic SMI 1.0 0.72 (0.60 - 0.88) 114 16728
615 Endometriosis genitourinary SMI 1.0 1.28 (1.11 - 1.48) 180 9622
356 Hereditary and idiopathic peripheral neuropathy neurological SMD 1.0 0.71 (0.58 - 0.87) 139 17286
577.3 Cyst and pseudocyst of pancreas digestive SMD 1.0 0.75 (0.64 - 0.89) 198 16514
681 Superficial cellulitis and abscess dermatologic SMI 1.0 0.88 (0.82 - 0.95) 823 16728
218 Benign neoplasm of uterus neoplasms SMD 1.0 1.25 (1.09 - 1.43) 384 8963
702.2 Seborrheic keratosis dermatologic SMD 1.0 1.35 (1.13 - 1.62) 194 17313
737 Curvature of spine musculoskeletal SMD 1.0 0.69 (0.55 - 0.86) 109 17323
289.4 Lymphadenitis hematopoietic SMI 1.0 0.88 (0.81 - 0.95) 766 15447
696 Psoriasis and related disorders dermatologic SMI 1.0 1.38 (1.13 - 1.67) 112 16765
350 Abnormal movement neurological SMI 1.0 0.83 (0.74 - 0.93) 371 17248
255 Disorders of adrenal glands endocrine/metabolic SMI 1.0 0.80 (0.71 - 0.92) 260 16939
289 Other diseases of blood and blood-forming organs hematopoietic SMD 1.0 0.74 (0.62 - 0.89) 173 15441
350.1 Abnormal involuntary movements neurological SMD 1.0 0.74 (0.61 - 0.89) 161 17242
965.1 Opiates and related narcotics causing adverse effects in therapeutic use injuries & poisonings SMD 1.0 0.76 (0.64 - 0.90) 210 15985
716 Other arthropathies musculoskeletal SMD 1.0 0.70 (0.56 - 0.87) 118 17063
433.8 Late effects of cerebrovascular disease circulatory system SMI 1.0 0.73 (0.60 - 0.88) 132 16761
578.1 Hematemesis digestive SMI 1.0 0.74 (0.62 - 0.89) 126 15485
350 Abnormal movement neurological SMD 1.0 0.81 (0.72 - 0.93) 371 17242
519.9 Symptoms involving respiratory system and other chest symptoms respiratory SMI 1.0 0.76 (0.64 - 0.90) 150 17375
184.1 Malignant neoplasm of ovary and other uterine adnexa neoplasms SMI 1.0 0.82 (0.73 - 0.93) 344 8833
196 Radiotherapy neoplasms SMI 1.0 0.84 (0.75 - 0.94) 381 14143
764 Sciatica symptoms SMI 1.0 1.24 (1.08 - 1.42) 243 17097
760 Back pain symptoms SMD 1.0 0.90 (0.84 - 0.96) 1497 16142
745 Pain in joint musculoskeletal SMD 1.0 0.90 (0.84 - 0.96) 1533 16106
426.91 Cardiac pacemaker in situ circulatory system SMI 1.0 0.76 (0.64 - 0.90) 211 12606
619 Noninflammatory female genital disorders genitourinary SMI 1.0 1.15 (1.05 - 1.26) 553 9601
416 Cardiomegaly circulatory system SMI 1.0 0.85 (0.77 - 0.94) 485 16494
540.1 Appendicitis digestive SMI 1.0 1.14 (1.05 - 1.24) 567 17046
250.41 Impaired fasting glucose endocrine/metabolic SMI 1.0 1.33 (1.11 - 1.60) 143 14753
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts neoplasms SMI 1.0 0.76 (0.64 - 0.91) 168 15030
208 Benign neoplasm of colon neoplasms SMI 1.0 1.14 (1.05 - 1.24) 676 16075
695.42 Systemic lupus erythematosus dermatologic SMI 1.0 0.73 (0.60 - 0.90) 104 16911
594.3 Calculus of ureter genitourinary SMI 1.0 1.24 (1.08 - 1.42) 227 16294
440 Atherosclerosis circulatory system SMD 1.0 0.73 (0.60 - 0.90) 145 16717
578.2 Blood in stool digestive SMI 1.0 0.86 (0.79 - 0.95) 519 15485
249 Secondary diabetes mellitus endocrine/metabolic SMI 1.0 0.78 (0.66 - 0.92) 164 14753
626 Disorders of menstruation and other abnormal bleeding from female genital tract genitourinary SMI 1.0 1.18 (1.06 - 1.32) 334 9274
695.4 Lupus (localized and systemic) dermatologic SMI 1.0 0.75 (0.62 - 0.90) 115 16911
560.4 Other intestinal obstruction digestive SMD 1.0 0.90 (0.83 - 0.96) 1300 11799
184.11 Malignant neoplasm of ovary neoplasms SMI 1.0 0.83 (0.73 - 0.94) 324 8833
800 Fracture of lower limb injuries & poisonings SMD 1.0 0.78 (0.66 - 0.92) 206 16753
605 Erectile dysfunction [ED] genitourinary SMI 1.0 1.31 (1.10 - 1.57) 147 6634
763 Thoracic or lumbosacral neuritis or radiculitis, unspecified symptoms SMI 1.0 1.28 (1.08 - 1.50) 173 17097
473 Diseases of the larynx and vocal cords respiratory SMI 1.0 0.79 (0.67 - 0.92) 183 16763
427.12 Paroxysmal ventricular tachycardia circulatory system SMI 1.0 0.72 (0.57 - 0.90) 101 12606
338 Pain neurological SMI 1.0 0.93 (0.89 - 0.98) 2138 15508
182 Malignant neoplasm of uterus neoplasms SMI 1.0 1.21 (1.07 - 1.38) 268 8582
442 Other aneurysm circulatory system SMD 1.0 0.80 (0.69 - 0.93) 281 16717
540 Appendiceal conditions digestive SMI 1.0 1.13 (1.04 - 1.23) 600 17046
199 Neoplasm of uncertain behavior neoplasms SMI 1.0 0.86 (0.78 - 0.95) 459 14143
514.2 Solitary pulmonary nodule respiratory SMI 1.0 0.85 (0.75 - 0.95) 385 14750
153 Colorectal cancer neoplasms SMD 1.0 0.89 (0.82 - 0.96) 1002 14710
250.24 Type 2 diabetes with neurological manifestations endocrine/metabolic SMI 1.0 1.28 (1.08 - 1.52) 162 14753
198.5 Secondary malignancy of brain/spine neoplasms SMD 1.0 0.77 (0.65 - 0.92) 180 14136
395 Heart valve disorders circulatory system SMD 1.0 0.84 (0.75 - 0.95) 466 17028
269 Proteinuria endocrine/metabolic SMD 1.0 0.72 (0.57 - 0.91) 103 17321
395.2 Nonrheumatic aortic valve disorders circulatory system SMD 1.0 0.77 (0.64 - 0.93) 198 17028
327.4 Insomnia neurological SMD 1.0 0.87 (0.78 - 0.96) 617 15923
550.1 Inguinal hernia digestive SMI 1.0 1.25 (1.07 - 1.47) 203 16384
720 Spinal stenosis musculoskeletal SMD 1.0 0.81 (0.69 - 0.94) 272 16752
292.1 Aphasia/speech disturbance mental disorders SMI 1.0 0.76 (0.63 - 0.92) 139 16104
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts neoplasms SMD 1.0 0.77 (0.64 - 0.93) 168 15023
110.1 Dermatophytosis infectious diseases SMD 1.0 0.78 (0.66 - 0.93) 194 16933
741 Symptoms and disorders of the joints musculoskeletal SMD 1.0 0.78 (0.65 - 0.93) 182 17434
174.11 Malignant neoplasm of female breast neoplasms SMI 1.0 0.87 (0.79 - 0.96) 548 8867
614.5 Inflammatory disease of cervix, vagina, and vulva genitourinary SMI 1.0 1.28 (1.07 - 1.53) 123 9622
317.1 Alcoholism mental disorders SMI 1.0 0.87 (0.79 - 0.96) 462 15504
771.1 Swelling of limb symptoms SMI 1.0 0.84 (0.74 - 0.95) 308 17144
333 Extrapyramidal disease and abnormal movement disorders neurological SMD 1.0 0.74 (0.60 - 0.92) 126 16348
348.2 Cerebral edema and compression of brain neurological SMI 1.0 0.76 (0.63 - 0.93) 112 16355
535.2 Atrophic gastritis digestive SMI 1.0 1.21 (1.05 - 1.39) 223 16078
153.2 Colon cancer neoplasms SMD 1.0 0.88 (0.80 - 0.96) 695 14710
706 Diseases of sebaceous glands dermatologic SMI 1.0 0.82 (0.71 - 0.95) 198 17313
564.9 Personal history of diseases of digestive system digestive SMD 1.0 0.78 (0.65 - 0.93) 174 11799
253 Disorders of the pituitary gland and its hypothalamic control endocrine/metabolic SMI 1.0 0.75 (0.61 - 0.93) 103 16939
054 Herpes simplex infectious diseases SMI 1.0 0.78 (0.66 - 0.94) 135 16473
281 Other deficiency anemia hematopoietic SMD 1.0 0.74 (0.59 - 0.93) 121 14700
614 Inflammatory diseases of female pelvic organs genitourinary SMI 1.0 1.15 (1.04 - 1.27) 402 9622
574.11 Cholelithiasis with acute cholecystitis digestive SMD 1.0 0.74 (0.60 - 0.93) 116 15841
368 Visual disturbances sense organs SMD 1.0 0.81 (0.69 - 0.95) 228 17382
537 Other disorders of stomach and duodenum digestive SMD 1.0 0.88 (0.80 - 0.97) 666 16072
180.1 Cervical cancer neoplasms SMD 1.0 0.76 (0.61 - 0.93) 133 8561
261.4 Vitamin D deficiency endocrine/metabolic SMD 1.0 0.84 (0.74 - 0.96) 359 15668
244.2 Acquired hypothyroidism endocrine/metabolic SMD 1.0 0.73 (0.58 - 0.93) 108 16096
433 Cerebrovascular disease circulatory system SMI 1.0 0.89 (0.82 - 0.97) 760 16761
611 Abnormal findings on mammogram or breast exam genitourinary SMD 1.0 1.28 (1.06 - 1.55) 185 17356
961.1 Poisoning/allergy of sulfonamides injuries & poisonings SMD 1.0 0.82 (0.70 - 0.95) 255 15985
261.4 Vitamin D deficiency endocrine/metabolic SMI 1.0 0.86 (0.76 - 0.96) 359 15673
465.2 Acute pharyngitis respiratory SMD 1.0 1.33 (1.07 - 1.66) 137 17227
442 Other aneurysm circulatory system SMI 1.0 0.84 (0.73 - 0.96) 281 16724
317 Alcohol-related disorders mental disorders SMI 1.0 0.88 (0.81 - 0.97) 513 15504
807 Fracture of ribs injuries & poisonings SMD 1.0 1.31 (1.07 - 1.61) 154 16753
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus neoplasms SMD 1.0 0.87 (0.78 - 0.97) 506 14710
628 Ovarian cyst genitourinary SMI 1.0 1.14 (1.03 - 1.27) 384 9274
626.1 Irregular menstrual cycle/bleeding genitourinary SMI 1.0 1.21 (1.04 - 1.39) 188 9274
184 Cancer of other female genital organs neoplasms SMI 1.0 0.86 (0.77 - 0.97) 382 8833
317.11 Alcoholic liver damage mental disorders SMI 1.0 0.84 (0.73 - 0.96) 225 15504
442.1 Aortic aneurysm circulatory system SMI 1.0 0.79 (0.65 - 0.95) 159 16724
340 Migraine neurological SMI 1.0 1.14 (1.03 - 1.26) 403 16892
687.1 Rash and other nonspecific skin eruption dermatologic SMI 1.0 0.88 (0.79 - 0.97) 417 16836
260.6 Anorexia endocrine/metabolic SMD 1.0 0.83 (0.72 - 0.96) 302 15668
208 Benign neoplasm of colon neoplasms SMD 1.0 1.13 (1.03 - 1.25) 676 16068
216 Benign neoplasm of skin neoplasms SMD 1.0 1.26 (1.05 - 1.51) 197 17322
476 Allergic rhinitis respiratory SMD 1.0 1.22 (1.04 - 1.44) 250 16757
619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament genitourinary SMI 1.0 1.19 (1.03 - 1.36) 221 9601
327.7 Sleep related movement disorders neurological SMI 1.0 1.31 (1.05 - 1.62) 104 15928
580 Nephritis; nephrosis; renal sclerosis genitourinary SMI 1.0 0.80 (0.67 - 0.96) 139 14825
159.2 Malignant neoplasm of small intestine, including duodenum neoplasms SMI 1.0 0.78 (0.64 - 0.95) 117 15030
174.1 Breast cancer [female] neoplasms SMI 1.0 0.89 (0.81 - 0.98) 561 8867
555 Inflammatory bowel disease and other gastroenteritis and colitis digestive SMD 1.0 0.88 (0.80 - 0.98) 650 11799
196 Radiotherapy neoplasms SMD 1.0 0.86 (0.76 - 0.97) 381 14136
199 Neoplasm of uncertain behavior neoplasms SMD 1.0 0.87 (0.77 - 0.97) 459 14136
626.1 Irregular menstrual cycle/bleeding genitourinary SMD 1.0 1.28 (1.05 - 1.56) 188 9271
840 Sprains and strains injuries & poisonings SMI 1.0 1.26 (1.04 - 1.51) 120 17452
627 Menopausal and postmenopausal disorders genitourinary SMD 1.0 1.21 (1.04 - 1.42) 254 9271
531.4 Peptic ulcer, site unspecified digestive SMI 1.0 0.81 (0.68 - 0.97) 154 17236
496 Chronic airway obstruction respiratory SMI 1.0 0.89 (0.81 - 0.98) 577 16329
751.2 Congenital anomalies of urinary system congenital anomalies SMI 1.0 0.79 (0.65 - 0.96) 113 17411
599.2 Retention of urine genitourinary SMD 1.0 0.87 (0.77 - 0.98) 440 15860
747 Cardiac and circulatory congenital anomalies congenital anomalies SMD 1.0 0.77 (0.63 - 0.96) 124 17515
441 Vascular insufficiency of intestine circulatory system SMD 1.0 0.82 (0.70 - 0.97) 228 16717
702 Degenerative skin conditions and other dermatoses dermatologic SMD 1.0 1.18 (1.03 - 1.36) 326 17100
949 Allergies, other injuries & poisonings SMD 1.0 0.84 (0.73 - 0.97) 287 16743
790.6 Other abnormal blood chemistry symptoms SMI 1.0 0.91 (0.85 - 0.99) 829 16697
555.21 Ulcerative colitis (chronic) digestive SMD 1.0 0.79 (0.64 - 0.97) 135 11799
386.9 Dizziness and giddiness (Light-headedness and vertigo) sense organs SMD 1.0 0.89 (0.81 - 0.98) 634 16965
586.4 Stricture/obstruction of ureter genitourinary SMI 1.0 0.82 (0.69 - 0.97) 166 14825
426.32 Left bundle branch block circulatory system SMI 1.0 0.83 (0.71 - 0.97) 239 12606
599.9 Other abnormality of urination genitourinary SMI 1.0 1.19 (1.02 - 1.39) 204 15864
290.1 Dementias mental disorders SMD 1.0 0.83 (0.71 - 0.97) 312 16099
720.1 Spinal stenosis of lumbar region musculoskeletal SMD 1.0 0.80 (0.67 - 0.97) 176 16752
496.1 Emphysema respiratory SMD 1.0 0.77 (0.62 - 0.97) 121 16322
300.11 Generalized anxiety disorder mental disorders SMI 1.0 0.85 (0.74 - 0.98) 239 14166
450 Noninfectious disorders of lymphatic channels circulatory system SMI 1.0 0.80 (0.65 - 0.97) 119 17527
189.2 Cancer of bladder neoplasms SMD 1.0 0.85 (0.74 - 0.98) 333 17032
242 Thyrotoxicosis with or without goiter endocrine/metabolic SMI 1.0 0.78 (0.63 - 0.97) 103 16103
242 Thyrotoxicosis with or without goiter endocrine/metabolic SMD 1.0 0.76 (0.60 - 0.97) 103 16096
174 Breast cancer neoplasms SMI 1.0 0.90 (0.82 - 0.99) 570 16350
496.1 Emphysema respiratory SMI 1.0 0.79 (0.64 - 0.97) 121 16329
528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue digestive SMD 1.0 0.81 (0.67 - 0.97) 161 17378
172.1 Melanomas of skin, dx or hx neoplasms SMI 1.0 0.79 (0.64 - 0.97) 112 17160
695.42 Systemic lupus erythematosus dermatologic SMD 1.0 0.76 (0.60 - 0.97) 104 16904
350.1 Abnormal involuntary movements neurological SMI 1.0 0.82 (0.70 - 0.98) 161 17248
070 Viral hepatitis infectious diseases SMI 1.0 0.90 (0.82 - 0.99) 570 16473
211 Benign neoplasm of other parts of digestive system neoplasms SMD 1.0 0.81 (0.68 - 0.98) 168 15134
531.2 Gastric ulcer digestive SMD 1.0 0.78 (0.63 - 0.97) 125 17229
512.2 Painful respiration respiratory SMD 1.0 0.81 (0.68 - 0.98) 175 15031
250.22 Type 2 diabetes with renal manifestations endocrine/metabolic SMI 1.0 1.20 (1.02 - 1.41) 195 14753
189.21 Malignant neoplasm of bladder neoplasms SMD 1.0 0.85 (0.74 - 0.98) 321 17032
180 Cervical cancer and dysplasia neoplasms SMD 1.0 0.80 (0.65 - 0.98) 148 8561
574.12 Cholelithiasis with other cholecystitis digestive SMD 1.0 0.81 (0.67 - 0.98) 166 15841
614.3 Pelvic inflammatory disease (PID) genitourinary SMD 1.0 0.83 (0.70 - 0.98) 220 9617
426.2 Atrioventricular [AV] block circulatory system SMI 1.0 0.82 (0.69 - 0.98) 203 12606
261.2 Vitamin B-complex deficiencies endocrine/metabolic SMI 1.0 0.82 (0.69 - 0.98) 166 15673
574.1 Cholelithiasis digestive SMI 1.0 1.09 (1.01 - 1.18) 784 15847
351 Other peripheral nerve disorders neurological SMD 1.0 0.84 (0.73 - 0.98) 254 17138
155 Cancer of liver and intrahepatic bile duct neoplasms SMD 1.0 0.87 (0.77 - 0.99) 391 15023
418 Nonspecific chest pain circulatory system SMI 1.0 1.07 (1.01 - 1.13) 1425 16212
550.1 Inguinal hernia digestive SMD 1.0 1.22 (1.02 - 1.46) 203 16378
979 Adverse drug events and drug allergies injuries & poisonings SMD 1.0 0.78 (0.62 - 0.98) 112 15985
695 Erythematous conditions dermatologic SMI 1.0 0.88 (0.79 - 0.99) 349 16956
296.1 Bipolar mental disorders SMI 1.0 1.15 (1.01 - 1.31) 249 14166
571.81 Portal hypertension digestive SMI 1.0 0.88 (0.78 - 0.99) 319 13915
574.2 Calculus of bile duct digestive SMI 1.0 0.85 (0.74 - 0.99) 222 15847
550.4 Umbilical hernia digestive SMD 1.0 0.83 (0.69 - 0.99) 189 16378
216.1 Screening for malignant neoplasms of the skin neoplasms SMD 1.0 1.28 (1.02 - 1.60) 125 17322
803 Fracture of upper limb injuries & poisonings SMD 1.0 0.81 (0.67 - 0.99) 156 16753
473 Diseases of the larynx and vocal cords respiratory SMD 1.0 0.83 (0.69 - 0.99) 182 16757
411.8 Other chronic ischemic heart disease, unspecified circulatory system SMI 1.0 0.79 (0.63 - 0.99) 103 16271
939 Atopic/contact dermatitis due to other or unspecified dermatologic SMI 1.0 0.89 (0.81 - 0.99) 416 16750
594 Urinary calculus genitourinary SMD 1.0 1.10 (1.00 - 1.19) 882 16288
250.4 Abnormal glucose endocrine/metabolic SMI 1.0 1.10 (1.00 - 1.20) 667 14753
368 Visual disturbances sense organs SMI 1.0 0.87 (0.75 - 0.99) 228 17389
442.1 Aortic aneurysm circulatory system SMD 1.0 0.81 (0.67 - 0.99) 159 16717
578.8 Hemorrhage of rectum and anus digestive SMD 1.0 1.17 (1.01 - 1.37) 277 15478
155.1 Malignant neoplasm of liver, primary neoplasms SMI 1.0 0.87 (0.75 - 1.00) 254 15030
714 Rheumatoid arthritis and other inflammatory polyarthropathies musculoskeletal SMI 1.0 0.86 (0.74 - 1.00) 213 17191
796 Elevated prostate specific antigen [PSA] genitourinary SMD 1.0 1.29 (1.01 - 1.65) 108 6259
721 Spondylosis and allied disorders musculoskeletal SMD 1.0 0.88 (0.77 - 1.00) 369 16752
585.33 Chronic Kidney Disease, Stage III genitourinary SMI 1.0 0.87 (0.76 - 1.00) 300 14825
569.2 Gastrointestinal complications digestive SMI 1.0 0.89 (0.79 - 1.00) 310 14836
357 Inflammatory and toxic neuropathy neurological SMI 1.0 0.85 (0.72 - 1.00) 179 17292
295 Schizophrenia and other psychotic disorders mental disorders SMI 1.0 0.85 (0.73 - 1.00) 184 14166
626 Disorders of menstruation and other abnormal bleeding from female genital tract genitourinary SMD 1.0 1.16 (1.00 - 1.35) 334 9271
608 Other disorders of male genital organs genitourinary SMI 1.0 1.19 (1.00 - 1.43) 136 6634
327.7 Sleep related movement disorders neurological SMD 1.0 0.79 (0.62 - 1.00) 104 15923
535.9 Gastritis and duodenitis, NOS digestive SMD 1.0 1.21 (1.00 - 1.46) 182 16072
721.1 Spondylosis without myelopathy musculoskeletal SMD 1.0 0.87 (0.76 - 1.00) 333 16752
579 Other symptoms involving abdomen and pelvis digestive SMI 1.0 0.93 (0.87 - 1.00) 932 15485
555.2 Ulcerative colitis digestive SMD 1.0 0.87 (0.76 - 1.00) 321 11799
965 Poisoning by analgesics, antipyretics, and antirheumatics injuries & poisonings SMI 1.0 0.85 (0.72 - 1.00) 164 15992
189.2 Cancer of bladder neoplasms SMI 1.0 1.13 (1.00 - 1.29) 333 17039
110.1 Dermatophytosis infectious diseases SMI 1.0 1.17 (0.99 - 1.37) 194 16940
379 Other disorders of eye sense organs SMI 1.0 1.14 (0.99 - 1.32) 248 17164
573.3 Hepatomegaly digestive SMI 1.0 0.87 (0.75 - 1.01) 201 13915
722 Intervertebral disc disorders musculoskeletal SMD 1.0 0.88 (0.77 - 1.01) 336 16752
695.4 Lupus (localized and systemic) dermatologic SMD 1.0 0.80 (0.64 - 1.01) 115 16904
389 Hearing loss sense organs SMI 1.0 0.89 (0.80 - 1.00) 386 17258
743.11 Osteoporosis NOS musculoskeletal SMD 1.0 1.13 (0.99 - 1.29) 383 16912
379.2 Disorders of vitreous body sense organs SMI 1.0 1.16 (0.99 - 1.37) 190 17164
599.5 Frequency of urination and polyuria genitourinary SMI 1.0 1.10 (0.99 - 1.23) 423 15864
727 Other disorders of synovium, tendon, and bursa musculoskeletal SMI 1.0 1.16 (0.99 - 1.37) 171 16973
761 Cervicalgia symptoms SMD 1.0 1.13 (0.99 - 1.29) 381 17258
571.51 Cirrhosis of liver without mention of alcohol digestive SMI 1.0 0.91 (0.83 - 1.01) 534 13915
586 Other disorders of the kidney and ureters genitourinary SMI 1.0 0.93 (0.86 - 1.01) 857 14825
184.11 Malignant neoplasm of ovary neoplasms SMD 1.0 0.88 (0.77 - 1.01) 324 8828
362.2 Degeneration of macula and posterior pole of retina sense organs SMD 1.0 1.17 (0.99 - 1.39) 223 16998
395 Heart valve disorders circulatory system SMI 1.0 0.90 (0.81 - 1.01) 466 17035
287.31 Primary thrombocytopenia hematopoietic SMI 1.0 0.83 (0.68 - 1.02) 110 16149
293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] mental disorders SMD 1.0 0.82 (0.67 - 1.02) 131 17499
339 Other headache syndromes neurological SMD 1.0 0.89 (0.79 - 1.01) 407 16885
473.4 Voice disturbance respiratory SMI 1.0 0.84 (0.69 - 1.02) 129 16763
564.1 Irritable Bowel Syndrome digestive SMI 1.0 0.87 (0.75 - 1.01) 204 11805
740.9 Osteoarthrosis NOS musculoskeletal SMI 1.0 1.13 (0.99 - 1.30) 263 17082
535 Gastritis and duodenitis digestive SMD 1.0 1.10 (0.99 - 1.22) 608 16072
800.1 Fracture of neck of femur injuries & poisonings SMI 1.0 0.83 (0.67 - 1.02) 114 16757
401.3 Other hypertensive complications circulatory system SMI 1.0 0.85 (0.71 - 1.02) 139 13223
536.8 Dyspepsia and other specified disorders of function of stomach digestive SMD 1.0 1.16 (0.98 - 1.38) 218 16072
172.1 Melanomas of skin, dx or hx neoplasms SMD 1.0 0.81 (0.65 - 1.03) 112 17153
279.7 Other immunological findings endocrine/metabolic SMI 1.0 0.83 (0.68 - 1.02) 102 17084
172 Skin cancer neoplasms SMI 1.0 0.90 (0.80 - 1.01) 388 17160
465 Acute upper respiratory infections of multiple or unspecified sites respiratory SMI 1.0 1.11 (0.98 - 1.24) 319 17234
367 Disorders of refraction and accommodation; blindness and low vision sense organs SMD 1.0 0.87 (0.75 - 1.02) 251 17388
555.1 Regional enteritis digestive SMD 1.0 0.89 (0.78 - 1.02) 351 11799
464 Acute sinusitis respiratory SMI 1.0 1.19 (0.97 - 1.44) 109 17234
411.2 Myocardial infarction circulatory system SMI 1.0 0.91 (0.81 - 1.02) 423 16271
512.2 Painful respiration respiratory SMI 1.0 0.87 (0.74 - 1.02) 176 15037
726.1 Enthesopathy musculoskeletal SMI 1.0 1.19 (0.97 - 1.45) 112 16973
949 Allergies, other injuries & poisonings SMI 1.0 0.90 (0.79 - 1.02) 287 16750
706 Diseases of sebaceous glands dermatologic SMD 1.0 1.17 (0.98 - 1.40) 198 17306
614 Inflammatory diseases of female pelvic organs genitourinary SMD 1.0 0.90 (0.79 - 1.02) 402 9617
615 Endometriosis genitourinary SMD 1.0 1.18 (0.97 - 1.44) 180 9617
720 Spinal stenosis musculoskeletal SMI 1.0 1.13 (0.98 - 1.29) 272 16756
209 Neuroendocrine tumors neoplasms SMI 1.0 0.88 (0.75 - 1.02) 199 17447
930 Allergic reaction to food injuries & poisonings SMD 1.0 0.83 (0.67 - 1.04) 127 16743
568.1 Peritoneal adhesions (postoperative) (postinfection) digestive SMI 1.0 0.89 (0.78 - 1.02) 259 14836
760 Back pain symptoms SMI 1.0 1.05 (0.99 - 1.11) 1500 16146
380.4 Impacted cerumen sense organs SMD 1.0 1.22 (0.96 - 1.56) 109 17506
722.6 Degeneration of intervertebral disc musculoskeletal SMD 1.0 0.86 (0.72 - 1.03) 183 16752
599.9 Other abnormality of urination genitourinary SMD 1.0 1.16 (0.97 - 1.39) 202 15860
296.2 Depression mental disorders SMI 1.0 0.96 (0.91 - 1.01) 1948 14166
916 Contusion injuries & poisonings SMI 1.0 0.90 (0.79 - 1.02) 276 17370
716 Other arthropathies musculoskeletal SMI 1.0 1.18 (0.97 - 1.43) 118 17069
789.1 Persistent vomiting symptoms SMD 1.0 0.84 (0.68 - 1.04) 130 13092
189.21 Malignant neoplasm of bladder neoplasms SMI 1.0 1.11 (0.98 - 1.27) 321 17039
571 Chronic liver disease and cirrhosis digestive SMI 1.0 1.05 (0.99 - 1.10) 1717 13915
395.1 Nonrheumatic mitral valve disorders circulatory system SMD 1.0 1.17 (0.97 - 1.41) 184 17028
395.1 Nonrheumatic mitral valve disorders circulatory system SMI 1.0 0.87 (0.74 - 1.03) 184 17035
871 Open wounds of extremities injuries & poisonings SMI 1.0 0.87 (0.74 - 1.03) 153 17226
250.3 Insulin pump user endocrine/metabolic SMI 1.0 1.08 (0.98 - 1.20) 487 14753
714.1 Rheumatoid arthritis musculoskeletal SMI 1.0 0.88 (0.75 - 1.03) 184 17191
530.2 Esophageal bleeding (varices/hemorrhage) digestive SMI 1.0 0.89 (0.77 - 1.03) 225 14903
184.1 Malignant neoplasm of ovary and other uterine adnexa neoplasms SMD 1.0 0.90 (0.79 - 1.03) 344 8828
611.3 Lump or mass in breast genitourinary SMI 1.0 0.85 (0.69 - 1.04) 104 17363
187 Cancer of other male genital organs neoplasms SMI 1.0 1.12 (0.97 - 1.30) 189 6826
433.1 Occlusion and stenosis of precerebral arteries circulatory system SMD 1.0 0.84 (0.67 - 1.05) 127 16754
411.4 Coronary atherosclerosis circulatory system SMI 1.0 1.06 (0.98 - 1.15) 1024 16271
586.2 Cyst of kidney, acquired genitourinary SMD 1.0 1.21 (0.95 - 1.54) 115 14818
396 Abnormal heart sounds circulatory system SMI 1.0 0.84 (0.68 - 1.05) 102 17035
722.1 Displacement of intervertebral disc musculoskeletal SMI 1.0 1.17 (0.96 - 1.43) 105 16756
716.9 Arthropathy NOS musculoskeletal SMI 1.0 1.18 (0.95 - 1.44) 106 17069
565 Anal and rectal conditions digestive SMD 1.0 0.92 (0.83 - 1.02) 541 14829
070 Viral hepatitis infectious diseases SMD 1.0 0.92 (0.83 - 1.02) 570 16466
338.2 Chronic pain neurological SMI 1.0 0.95 (0.89 - 1.02) 1089 15508
316 Substance addiction and disorders mental disorders SMI 1.0 0.93 (0.84 - 1.02) 443 15504
625 Pain and other symptoms associated with female genital organs genitourinary SMI 1.0 1.09 (0.97 - 1.21) 366 9715
257.1 Testicular hypofunction endocrine/metabolic SMI 1.0 1.17 (0.95 - 1.43) 101 7161
681.7 Cellulitis and abscess of trunk dermatologic SMI 1.0 0.91 (0.81 - 1.03) 298 16728
599.3 Dysuria genitourinary SMI 1.0 1.07 (0.98 - 1.17) 584 15864
257 Testicular dysfunction endocrine/metabolic SMI 1.0 1.17 (0.95 - 1.43) 102 7161
457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin circulatory system SMI 1.0 1.07 (0.98 - 1.17) 706 15244
701 Other hypertrophic and atrophic conditions of skin dermatologic SMI 1.0 1.11 (0.97 - 1.26) 240 17379
454 Varicose veins circulatory system SMI 1.0 0.87 (0.73 - 1.05) 145 15244
536.8 Dyspepsia and other specified disorders of function of stomach digestive SMI 1.0 0.90 (0.78 - 1.04) 218 16078
433.3 Cerebral ischemia circulatory system SMI 1.0 0.92 (0.81 - 1.03) 377 16761
574.3 Cholecystitis without cholelithiasis digestive SMI 1.0 0.92 (0.81 - 1.03) 334 15847
455 Hemorrhoids circulatory system SMD 1.0 1.09 (0.97 - 1.23) 464 15238
579.2 Splenomegaly digestive SMI 1.0 0.92 (0.81 - 1.03) 300 15485
720.1 Spinal stenosis of lumbar region musculoskeletal SMI 1.0 1.13 (0.95 - 1.35) 176 16756
187.2 Malignant neoplasm of testis neoplasms SMD 1.0 1.15 (0.95 - 1.40) 172 6824
600 Hyperplasia of prostate genitourinary SMD 1.0 1.09 (0.97 - 1.23) 539 6259
350.2 Abnormality of gait neurological SMI 1.0 0.89 (0.75 - 1.05) 182 17248
789.1 Persistent vomiting symptoms SMI 1.0 0.88 (0.74 - 1.05) 130 13099
530 Diseases of esophagus digestive SMI 1.0 0.97 (0.92 - 1.01) 2393 14903
747 Cardiac and circulatory congenital anomalies congenital anomalies SMI 1.0 0.88 (0.73 - 1.05) 124 17522
743.1 Osteoporosis musculoskeletal SMD 1.0 1.10 (0.96 - 1.24) 406 16912
175 Acquired absence of breast neoplasms SMD 1.0 0.87 (0.71 - 1.06) 149 8757
296 Mood disorders mental disorders SMI 1.0 0.97 (0.92 - 1.01) 2153 14166
355.1 Chronic pain syndrome neurological SMI 1.0 0.89 (0.75 - 1.05) 149 17143
594.3 Calculus of ureter genitourinary SMD 1.0 1.12 (0.95 - 1.33) 227 16288
261.2 Vitamin B-complex deficiencies endocrine/metabolic SMD 1.0 0.87 (0.72 - 1.06) 165 15668
300.11 Generalized anxiety disorder mental disorders SMD 1.0 0.89 (0.76 - 1.05) 239 14160
961.1 Poisoning/allergy of sulfonamides injuries & poisonings SMI 1.0 0.91 (0.79 - 1.04) 255 15992
564.1 Irritable Bowel Syndrome digestive SMD 1.0 1.13 (0.95 - 1.35) 204 11799
366 Cataract sense organs SMI 1.0 1.07 (0.97 - 1.19) 526 17120
578.2 Blood in stool digestive SMD 1.0 0.93 (0.83 - 1.04) 519 15478
694.2 Other dyschromia dermatologic SMI 1.0 0.88 (0.74 - 1.06) 134 16956
366.2 Senile cataract sense organs SMI 1.0 1.10 (0.96 - 1.25) 272 17120
761 Cervicalgia symptoms SMI 1.0 1.07 (0.96 - 1.19) 385 17261
577.1 Acute pancreatitis digestive SMI 1.0 0.94 (0.85 - 1.03) 495 16521
531.4 Peptic ulcer, site unspecified digestive SMD 1.0 0.88 (0.72 - 1.07) 154 17229
724 Other and unspecified disorders of back musculoskeletal SMD 1.0 0.88 (0.72 - 1.08) 143 16752
611.3 Lump or mass in breast genitourinary SMD 1.0 1.17 (0.92 - 1.51) 104 17356
479 Other upper respiratory disease respiratory SMI 1.0 0.92 (0.80 - 1.05) 254 16763
619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament genitourinary SMD 1.0 1.12 (0.94 - 1.33) 221 9596
618 Genital prolapse genitourinary SMD 1.0 1.16 (0.92 - 1.47) 114 10035
184 Cancer of other female genital organs neoplasms SMD 1.0 0.92 (0.81 - 1.05) 382 8828
473.4 Voice disturbance respiratory SMD 1.0 0.87 (0.70 - 1.08) 128 16757
241.1 Nontoxic uninodular goiter endocrine/metabolic SMD 1.0 1.15 (0.92 - 1.45) 122 16096
379.2 Disorders of vitreous body sense organs SMD 1.0 1.12 (0.93 - 1.35) 190 17157
594.1 Calculus of kidney genitourinary SMD 1.0 1.06 (0.96 - 1.17) 694 16288
579.8 Nonspecific abnormal findings in stool contents digestive SMD 1.0 1.11 (0.94 - 1.30) 237 15478
698 Pruritus and related conditions dermatologic SMD 1.0 0.90 (0.76 - 1.07) 213 17426
770 Myalgia and myositis unspecified symptoms SMI 1.0 1.07 (0.96 - 1.18) 403 17243
356 Hereditary and idiopathic peripheral neuropathy neurological SMI 1.0 0.89 (0.74 - 1.08) 140 17292
681.5 Cellulitis and abscess of leg, except foot dermatologic SMI 1.0 0.89 (0.74 - 1.08) 131 16728
608 Other disorders of male genital organs genitourinary SMD 1.0 1.14 (0.92 - 1.42) 136 6632
296.22 Major depressive disorder mental disorders SMI 1.0 0.96 (0.89 - 1.03) 805 14166
535.2 Atrophic gastritis digestive SMD 1.0 1.11 (0.94 - 1.31) 223 16072
401.22 Hypertensive chronic kidney disease circulatory system SMI 1.0 0.92 (0.80 - 1.06) 290 13223
428.4 Heart failure with preserved EF [Diastolic heart failure] circulatory system SMI 1.0 1.12 (0.92 - 1.36) 149 16709
577.3 Cyst and pseudocyst of pancreas digestive SMI 1.0 0.91 (0.78 - 1.06) 198 16521
614.3 Pelvic inflammatory disease (PID) genitourinary SMI 1.0 1.08 (0.94 - 1.24) 220 9622
158 Neoplasm of unspecified nature of digestive system neoplasms SMI 1.0 0.91 (0.78 - 1.07) 207 15030
426.21 First degree AV block circulatory system SMI 1.0 0.88 (0.71 - 1.09) 135 12606
187.2 Malignant neoplasm of testis neoplasms SMI 1.0 1.09 (0.94 - 1.27) 172 6826
741 Symptoms and disorders of the joints musculoskeletal SMI 1.0 1.10 (0.93 - 1.28) 183 17440
564.9 Personal history of diseases of digestive system digestive SMI 1.0 0.91 (0.77 - 1.07) 174 11805
495.2 Asthma with exacerbation respiratory SMD 1.0 0.87 (0.69 - 1.11) 103 16322
763 Thoracic or lumbosacral neuritis or radiculitis, unspecified symptoms SMD 1.0 0.90 (0.75 - 1.09) 172 17093
694 Dyschromia and Vitiligo dermatologic SMI 1.0 0.91 (0.76 - 1.08) 149 16956
729 Other disorders of soft tissues musculoskeletal SMI 1.0 0.92 (0.80 - 1.06) 227 16973
611 Abnormal findings on mammogram or breast exam genitourinary SMI 1.0 0.92 (0.78 - 1.07) 185 17363
395.6 Heart valve replaced circulatory system SMI 1.0 0.90 (0.74 - 1.09) 138 17035
586.2 Cyst of kidney, acquired genitourinary SMI 1.0 1.12 (0.91 - 1.38) 115 14825
457.3 Encounter for long-term (current) use of aspirin circulatory system SMI 1.0 1.05 (0.96 - 1.16) 581 15244
530.11 GERD digestive SMI 1.0 1.03 (0.98 - 1.09) 1746 14903
257.1 Testicular hypofunction endocrine/metabolic SMD 1.0 0.88 (0.69 - 1.12) 101 7159
733 Other disorders of bone and cartilage musculoskeletal SMD 1.0 0.91 (0.76 - 1.09) 189 17062
401.2 Hypertensive heart and/or renal disease circulatory system SMI 1.0 0.94 (0.84 - 1.05) 465 13223
174.1 Breast cancer [female] neoplasms SMD 1.0 0.94 (0.85 - 1.05) 561 8862
800.1 Fracture of neck of femur injuries & poisonings SMD 1.0 0.88 (0.70 - 1.12) 114 16753
433.31 Transient cerebral ischemia circulatory system SMI 1.0 0.94 (0.83 - 1.06) 358 16761
562.2 Diverticulitis digestive SMD 1.0 0.95 (0.87 - 1.05) 754 11799
174.11 Malignant neoplasm of female breast neoplasms SMD 1.0 0.95 (0.85 - 1.05) 548 8862
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum neoplasms SMD 1.0 0.95 (0.86 - 1.05) 627 15023
175 Acquired absence of breast neoplasms SMI 1.0 0.91 (0.77 - 1.09) 149 8762
110.11 Dermatophytosis of nail infectious diseases SMI 1.0 1.12 (0.90 - 1.39) 111 16940
619 Noninflammatory female genital disorders genitourinary SMD 1.0 1.06 (0.95 - 1.18) 553 9596
272.13 Mixed hyperlipidemia endocrine/metabolic SMD 1.0 0.90 (0.72 - 1.12) 129 14755
574.12 Cholelithiasis with other cholecystitis digestive SMI 1.0 1.09 (0.92 - 1.28) 166 15847
155.1 Malignant neoplasm of liver, primary neoplasms SMD 1.0 0.93 (0.79 - 1.08) 254 15023
250.42 Other abnormal glucose endocrine/metabolic SMI 1.0 1.05 (0.95 - 1.15) 548 14753
332 Parkinson's disease neurological SMI 1.0 0.89 (0.70 - 1.13) 113 16355
440 Atherosclerosis circulatory system SMI 1.0 0.91 (0.75 - 1.10) 145 16724
850 Hemorrhage or hematoma complicating a procedure injuries & poisonings SMI 1.0 0.92 (0.77 - 1.09) 149 16976
293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] mental disorders SMI 1.0 0.91 (0.76 - 1.10) 131 17506
965.1 Opiates and related narcotics causing adverse effects in therapeutic use injuries & poisonings SMI 1.0 0.93 (0.80 - 1.08) 210 15992
362 Other retinal disorders sense organs SMI 1.0 0.94 (0.83 - 1.07) 340 17005
618 Genital prolapse genitourinary SMI 1.0 1.09 (0.90 - 1.33) 115 10039
257 Testicular dysfunction endocrine/metabolic SMD 1.0 0.90 (0.71 - 1.14) 102 7159
519.9 Symptoms involving respiratory system and other chest symptoms respiratory SMD 1.0 0.91 (0.75 - 1.12) 150 17368
241.1 Nontoxic uninodular goiter endocrine/metabolic SMI 1.0 1.09 (0.90 - 1.32) 122 16103
476 Allergic rhinitis respiratory SMI 1.0 1.06 (0.93 - 1.21) 250 16763
241 Nontoxic nodular goiter endocrine/metabolic SMI 1.0 1.07 (0.92 - 1.26) 187 16103
433.21 Cerebral artery occlusion, with cerebral infarction circulatory system SMI 1.0 0.94 (0.81 - 1.08) 255 16761
411 Ischemic Heart Disease circulatory system SMI 1.0 0.97 (0.91 - 1.04) 1325 16271
433.2 Occlusion of cerebral arteries circulatory system SMI 1.0 0.94 (0.82 - 1.08) 260 16761
705.8 Hyperhidrosis dermatologic SMI 1.0 1.08 (0.90 - 1.31) 122 17313
185 Cancer of prostate neoplasms SMD 1.0 0.95 (0.84 - 1.07) 483 6259
840 Sprains and strains injuries & poisonings SMD 1.0 1.10 (0.88 - 1.39) 120 17447
159.2 Malignant neoplasm of small intestine, including duodenum neoplasms SMD 1.0 0.91 (0.73 - 1.14) 117 15023
593.1 Gross hematuria genitourinary SMD 1.0 0.91 (0.73 - 1.14) 127 15562
375.1 Dry eyes sense organs SMD 1.0 1.10 (0.88 - 1.38) 123 17157
805 Fracture of vertebral column without mention of spinal cord injury injuries & poisonings SMD 1.0 0.94 (0.81 - 1.09) 280 16753
174 Breast cancer neoplasms SMD 1.0 0.96 (0.86 - 1.07) 570 16343
415.2 Chronic pulmonary heart disease circulatory system SMI 1.0 0.94 (0.81 - 1.09) 227 16494
605 Erectile dysfunction [ED] genitourinary SMD 1.0 1.09 (0.88 - 1.34) 147 6632
244 Hypothyroidism endocrine/metabolic SMI 1.0 1.03 (0.96 - 1.10) 1245 16103
788 Syncope and collapse symptoms SMD 1.0 1.05 (0.93 - 1.19) 399 17240
158 Neoplasm of unspecified nature of digestive system neoplasms SMD 1.0 0.94 (0.79 - 1.11) 207 15023
530.14 Reflux esophagitis digestive SMD 1.0 1.07 (0.90 - 1.26) 226 14896
702.2 Seborrheic keratosis dermatologic SMI 1.0 1.06 (0.90 - 1.25) 194 17320
365 Glaucoma sense organs SMI 1.0 0.95 (0.81 - 1.10) 238 17050
701 Other hypertrophic and atrophic conditions of skin dermatologic SMD 1.0 0.94 (0.80 - 1.11) 239 17373
340 Migraine neurological SMD 1.0 0.95 (0.84 - 1.08) 403 16885
743.9 Osteopenia or other disorder of bone and cartilage musculoskeletal SMD 1.0 0.95 (0.81 - 1.10) 265 16912
530.14 Reflux esophagitis digestive SMI 1.0 0.95 (0.82 - 1.10) 226 14903
339 Other headache syndromes neurological SMI 1.0 1.04 (0.93 - 1.15) 407 16892
443.9 Peripheral vascular disease, unspecified circulatory system SMI 1.0 1.06 (0.89 - 1.26) 177 16724
216 Benign neoplasm of skin neoplasms SMI 1.0 0.95 (0.82 - 1.10) 197 17329
535.9 Gastritis and duodenitis, NOS digestive SMI 1.0 0.95 (0.81 - 1.11) 182 16078
366 Cataract sense organs SMD 1.0 0.96 (0.86 - 1.08) 526 17113
479 Other upper respiratory disease respiratory SMD 1.0 0.95 (0.81 - 1.11) 254 16757
350.2 Abnormality of gait neurological SMD 1.0 0.94 (0.78 - 1.13) 182 17242
599 Other symptoms/disorders or the urinary system genitourinary SMI 1.0 0.98 (0.93 - 1.04) 1481 15864
722.6 Degeneration of intervertebral disc musculoskeletal SMI 1.0 0.95 (0.80 - 1.12) 185 16756
371.3 Inflammation of eyelids sense organs SMD 1.0 1.08 (0.85 - 1.38) 106 17301
170 Cancer of bone and connective tissue neoplasms SMD 1.0 0.95 (0.83 - 1.10) 300 17339
380.4 Impacted cerumen sense organs SMI 1.0 1.07 (0.86 - 1.33) 109 17513
578.8 Hemorrhage of rectum and anus digestive SMI 1.0 1.04 (0.92 - 1.18) 277 15485
562 Diverticulosis and diverticulitis digestive SMD 1.0 0.98 (0.91 - 1.05) 1487 11799
721 Spondylosis and allied disorders musculoskeletal SMI 1.0 1.04 (0.92 - 1.17) 370 16756
809 Fracture of unspecified bones injuries & poisonings SMD 1.0 0.96 (0.85 - 1.09) 379 16753
216.1 Screening for malignant neoplasms of the skin neoplasms SMI 1.0 1.06 (0.87 - 1.28) 125 17329
250.41 Impaired fasting glucose endocrine/metabolic SMD 1.0 0.94 (0.76 - 1.16) 143 14747
172.2 Other non-epithelial cancer of skin neoplasms SMD 1.0 1.05 (0.90 - 1.22) 286 17153
172 Skin cancer neoplasms SMD 1.0 0.96 (0.85 - 1.10) 388 17153
800 Fracture of lower limb injuries & poisonings SMI 1.0 0.96 (0.82 - 1.11) 207 16757
443 Peripheral vascular disease circulatory system SMI 1.0 0.96 (0.82 - 1.12) 226 16724
530.1 Esophagitis, GERD and related diseases digestive SMI 1.0 0.99 (0.94 - 1.04) 2098 14903
721.1 Spondylosis without myelopathy musculoskeletal SMI 1.0 1.03 (0.91 - 1.17) 334 16756
705.8 Hyperhidrosis dermatologic SMD 1.0 1.06 (0.85 - 1.34) 122 17306
455 Hemorrhoids circulatory system SMI 1.0 1.03 (0.93 - 1.14) 464 15244
110 Dermatophytosis / Dermatomycosis infectious diseases SMI 1.0 1.04 (0.89 - 1.21) 216 16940
300.9 Posttraumatic stress disorder mental disorders SMI 1.0 1.05 (0.86 - 1.28) 106 14166
374 Other disorders of eyelids sense organs SMI 1.0 1.05 (0.85 - 1.30) 110 17308
496.2 Chronic bronchitis respiratory SMI 1.0 1.05 (0.85 - 1.29) 122 16329
241 Nontoxic nodular goiter endocrine/metabolic SMD 1.0 1.04 (0.87 - 1.26) 187 16096
170.2 Cancer of connective tissue neoplasms SMD 1.0 0.96 (0.83 - 1.12) 269 17339
318 Tobacco use disorder mental disorders SMI 1.0 1.01 (0.96 - 1.07) 1555 15504
332 Parkinson's disease neurological SMD 1.0 1.06 (0.83 - 1.35) 113 16348
157 Pancreatic cancer neoplasms SMD 1.0 0.97 (0.86 - 1.10) 440 15023
159.4 Malignant neoplasm of retroperitoneum and peritoneum neoplasms SMD 1.0 1.05 (0.85 - 1.31) 130 15023
389.1 Sensorineural hearing loss sense organs SMI 1.0 1.04 (0.88 - 1.22) 198 17258
279.7 Other immunological findings endocrine/metabolic SMD 1.0 1.06 (0.83 - 1.36) 102 17077
306 Other mental disorder mental disorders SMI 1.0 0.97 (0.86 - 1.10) 317 14166
292.3 Memory loss mental disorders SMD 1.0 0.95 (0.75 - 1.21) 112 16099
165 Cancer within the respiratory system neoplasms SMD 1.0 0.97 (0.82 - 1.14) 233 17396
722 Intervertebral disc disorders musculoskeletal SMI 1.0 0.97 (0.86 - 1.10) 338 16756
550.2 Diaphragmatic hernia digestive SMI 1.0 0.98 (0.86 - 1.10) 344 16384
722.1 Displacement of intervertebral disc musculoskeletal SMD 1.0 1.05 (0.83 - 1.34) 105 16752
365 Glaucoma sense organs SMD 1.0 0.97 (0.82 - 1.14) 238 17043
702 Degenerative skin conditions and other dermatoses dermatologic SMI 1.0 1.03 (0.90 - 1.16) 326 17106
619.4 Noninflammatory disorders of vagina genitourinary SMD 1.0 0.96 (0.78 - 1.18) 147 9596
367 Disorders of refraction and accommodation; blindness and low vision sense organs SMI 1.0 0.97 (0.85 - 1.12) 251 17395
173 Neoplasm of uncertain behavior of skin neoplasms SMD 1.0 0.96 (0.79 - 1.17) 164 17153
211 Benign neoplasm of other parts of digestive system neoplasms SMI 1.0 1.03 (0.88 - 1.22) 168 15141
274.1 Gout endocrine/metabolic SMI 1.0 1.03 (0.87 - 1.22) 184 17444
271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption endocrine/metabolic SMD 1.0 1.05 (0.83 - 1.33) 113 17523
187 Cancer of other male genital organs neoplasms SMD 1.0 1.04 (0.87 - 1.25) 189 6824
292.3 Memory loss mental disorders SMI 1.0 1.04 (0.84 - 1.30) 112 16104
427.9 Palpitations circulatory system SMD 1.0 0.97 (0.82 - 1.15) 224 12600
698 Pruritus and related conditions dermatologic SMI 1.0 0.97 (0.84 - 1.12) 213 17433
579.8 Nonspecific abnormal findings in stool contents digestive SMI 1.0 1.03 (0.89 - 1.18) 237 15485
574.11 Cholelithiasis with acute cholecystitis digestive SMI 1.0 1.04 (0.85 - 1.27) 116 15847
110.11 Dermatophytosis of nail infectious diseases SMD 1.0 0.96 (0.76 - 1.22) 111 16933
585.4 Chronic kidney disease, Stage I or II genitourinary SMI 1.0 1.04 (0.83 - 1.30) 102 14825
271 Disorders of carbohydrate transport and metabolism endocrine/metabolic SMD 1.0 1.04 (0.83 - 1.31) 116 17523
172.2 Other non-epithelial cancer of skin neoplasms SMI 1.0 0.98 (0.85 - 1.12) 286 17160
465.2 Acute pharyngitis respiratory SMI 1.0 0.97 (0.82 - 1.16) 137 17234
512.8 Cough respiratory SMI 1.0 1.01 (0.94 - 1.10) 807 15037
458.1 Orthostatic hypotension circulatory system SMD 1.0 0.96 (0.76 - 1.22) 109 16641
394 Rheumatic disease of the heart valves circulatory system SMI 1.0 0.97 (0.79 - 1.19) 123 17035
702.1 Actinic keratosis dermatologic SMD 1.0 1.03 (0.86 - 1.24) 188 17313
269 Proteinuria endocrine/metabolic SMI 1.0 1.03 (0.84 - 1.27) 103 17328
475 Chronic sinusitis respiratory SMI 1.0 1.02 (0.88 - 1.19) 194 16763
159.4 Malignant neoplasm of retroperitoneum and peritoneum neoplasms SMI 1.0 0.97 (0.80 - 1.18) 130 15030
593 Hematuria genitourinary SMI 1.0 0.99 (0.89 - 1.09) 453 15566
244.4 Hypothyroidism NOS endocrine/metabolic SMI 1.0 1.01 (0.94 - 1.08) 1116 16103
465 Acute upper respiratory infections of multiple or unspecified sites respiratory SMD 1.0 0.98 (0.85 - 1.13) 319 17227
790 Nonspecific findings on examination of blood symptoms SMI 1.0 1.03 (0.85 - 1.24) 136 16697
362.2 Degeneration of macula and posterior pole of retina sense organs SMI 1.0 0.98 (0.83 - 1.15) 223 17005
371 Inflammation of the eye sense organs SMD 1.0 1.03 (0.84 - 1.25) 158 17301
726 Peripheral enthesopathies and allied syndromes musculoskeletal SMD 1.0 0.98 (0.83 - 1.16) 218 16966
803 Fracture of upper limb injuries & poisonings SMI 1.0 0.98 (0.83 - 1.16) 156 16757
687 Symptoms affecting skin dermatologic SMI 1.0 1.02 (0.85 - 1.23) 133 16836
362 Other retinal disorders sense organs SMD 1.0 0.98 (0.86 - 1.13) 340 16998
386.9 Dizziness and giddiness (Light-headedness and vertigo) sense organs SMI 1.0 0.99 (0.91 - 1.08) 634 16972
743 Osteoporosis, osteopenia and pathological fracture musculoskeletal SMD 1.0 0.99 (0.90 - 1.09) 727 16912
514.2 Solitary pulmonary nodule respiratory SMD 1.0 0.98 (0.86 - 1.12) 385 14743
560.3 Peritoneal or intestinal adhesions digestive SMD 1.0 1.03 (0.83 - 1.26) 142 11799
726.1 Enthesopathy musculoskeletal SMD 1.0 0.97 (0.77 - 1.23) 112 16966
574 Cholelithiasis and cholecystitis digestive SMI 1.0 1.01 (0.94 - 1.08) 1050 15847
751.2 Congenital anomalies of urinary system congenital anomalies SMD 1.0 1.03 (0.82 - 1.30) 113 17405
687.4 Disturbance of skin sensation dermatologic SMI 1.0 0.99 (0.88 - 1.11) 320 16836
165.1 Cancer of bronchus; lung neoplasms SMD 1.0 0.98 (0.83 - 1.16) 225 17396
395.2 Nonrheumatic aortic valve disorders circulatory system SMI 1.0 0.98 (0.82 - 1.17) 198 17035
244.2 Acquired hypothyroidism endocrine/metabolic SMI 1.0 1.02 (0.83 - 1.26) 108 16103
704 Diseases of hair and hair follicles dermatologic SMI 1.0 0.98 (0.82 - 1.17) 134 17407
427.9 Palpitations circulatory system SMI 1.0 1.02 (0.88 - 1.17) 224 12606
371.3 Inflammation of eyelids sense organs SMI 1.0 1.02 (0.83 - 1.26) 106 17308
599.4 Urinary incontinence genitourinary SMI 1.0 1.01 (0.89 - 1.16) 283 15864
614.5 Inflammatory disease of cervix, vagina, and vulva genitourinary SMD 1.0 1.02 (0.82 - 1.29) 123 9617
374 Other disorders of eyelids sense organs SMD 1.0 0.98 (0.77 - 1.24) 110 17301
173 Neoplasm of uncertain behavior of skin neoplasms SMI 1.0 0.98 (0.83 - 1.17) 164 17160
151 Cancer of stomach neoplasms SMD 1.0 1.02 (0.86 - 1.20) 234 15023
209 Neuroendocrine tumors neoplasms SMD 1.0 1.02 (0.85 - 1.21) 199 17440
535 Gastritis and duodenitis digestive SMI 1.0 0.99 (0.91 - 1.08) 608 16078
389.1 Sensorineural hearing loss sense organs SMD 1.0 1.02 (0.85 - 1.22) 197 17252
379 Other disorders of eye sense organs SMD 1.0 1.01 (0.86 - 1.19) 248 17157
371 Inflammation of the eye sense organs SMI 1.0 0.99 (0.83 - 1.17) 158 17308
694.2 Other dyschromia dermatologic SMD 1.0 1.02 (0.82 - 1.26) 134 16949
687.4 Disturbance of skin sensation dermatologic SMD 1.0 1.01 (0.88 - 1.16) 318 16831
819 Skull and face fracture and other intercranial injury injuries & poisonings SMD 1.0 1.02 (0.80 - 1.30) 106 17488
593 Hematuria genitourinary SMD 1.0 1.01 (0.90 - 1.13) 453 15562
694 Dyschromia and Vitiligo dermatologic SMD 1.0 1.01 (0.83 - 1.24) 149 16949
727 Other disorders of synovium, tendon, and bursa musculoskeletal SMD 1.0 0.99 (0.82 - 1.20) 171 16966
351 Other peripheral nerve disorders neurological SMI 1.0 1.01 (0.88 - 1.15) 254 17143
807 Fracture of ribs injuries & poisonings SMI 1.0 1.01 (0.85 - 1.20) 154 16757
593.1 Gross hematuria genitourinary SMI 1.0 0.99 (0.81 - 1.21) 127 15566
809 Fracture of unspecified bones injuries & poisonings SMI 1.0 1.00 (0.89 - 1.11) 380 16757
250.1 Type 1 diabetes endocrine/metabolic SMI 1.0 0.99 (0.84 - 1.18) 147 14753
375.1 Dry eyes sense organs SMI 1.0 1.01 (0.83 - 1.22) 123 17164
429 Ill-defined descriptions and complications of heart disease circulatory system SMI 1.0 1.01 (0.82 - 1.24) 116 16709
599.5 Frequency of urination and polyuria genitourinary SMD 1.0 1.00 (0.88 - 1.13) 422 15860
433.1 Occlusion and stenosis of precerebral arteries circulatory system SMI 1.0 1.01 (0.82 - 1.24) 127 16761
702.1 Actinic keratosis dermatologic SMI 1.0 1.00 (0.84 - 1.18) 188 17320
590 Pyelonephritis genitourinary SMI 1.0 1.00 (0.90 - 1.11) 428 15566
272.11 Hypercholesterolemia endocrine/metabolic SMD 1.0 1.00 (0.87 - 1.16) 310 14755
599.3 Dysuria genitourinary SMD 1.0 1.00 (0.90 - 1.11) 583 15860
475 Chronic sinusitis respiratory SMD 1.0 1.00 (0.83 - 1.19) 194 16757
389 Hearing loss sense organs SMD 1.0 1.00 (0.88 - 1.14) 385 17252
704 Diseases of hair and hair follicles dermatologic SMD 1.0 1.00 (0.81 - 1.24) 134 17400
751 Genitourinary congenital anomalies congenital anomalies SMD 1.0 1.00 (0.82 - 1.23) 147 17405
619.4 Noninflammatory disorders of vagina genitourinary SMI 1.0 1.00 (0.84 - 1.18) 147 9601
070.3 Viral hepatitis C infectious diseases SMI 1.0 1.00 (0.89 - 1.12) 359 16473
464 Acute sinusitis respiratory SMD 1.0 1.00 (0.79 - 1.27) 109 17227
274 Gout and other crystal arthropathies endocrine/metabolic SMI 1.0 1.00 (0.85 - 1.18) 202 17444
366.2 Senile cataract sense organs SMD 1.0 1.00 (0.86 - 1.16) 272 17113
724 Other and unspecified disorders of back musculoskeletal SMI 1.0 1.00 (0.83 - 1.19) 143 16756
790 Nonspecific findings on examination of blood symptoms SMD 1.0 1.00 (0.81 - 1.24) 136 16690
562.1 Diverticulosis digestive SMD 1.0 1.00 (0.92 - 1.09) 886 11799

BibTeX

@article{
zambranochaves2024musclephewas,
title = {Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study},
journal = {eBioMedicine},
volume = {103},
pages = {105116},
year = {2024},
issn = {2352-3964},
doi = {https://doi.org/10.1016/j.ebiom.2024.105116},
url = {https://www.sciencedirect.com/science/article/pii/S2352396424001518},
author = {Juan M. {Zambrano Chaves} and Leon Lenchik and Isabel O. Gallegos and Louis Blankemeier and Daniel L. Rubin and Marc H. Willis and Akshay S. Chaudhari and Robert D. Boutin},
keywords = {Myopenia, Myosteatosis, Phenome wide association study, Computed tomography},
}